SEARCHCOHORTpediatrics, gastroenterology

cohort·pediatrics, gastroenterology, epidemiology, public health, observational study·PMC10191577

Incidence of Pediatric Eosinophilic Esophagitis and Characterization of the Stricturing Phenotype in Alberta, Canada

JPGN Reports · 3 authors, 2 centres

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TL;DR

This retrospective cohort study calculated the incidence of pediatric eosinophilic esophagitis (EoE) in Alberta, Canada, and characterized cases with esophageal narrowing. It found a high incidence rate and that 10% of patients showed esophageal narrowing, with no major adverse events from dilations.

Full summary

270 CHARS

Incidence rates were calculated using census data. Pain was reported after 15% of scopes overall but was more frequent (50%) in scopes with focal strictures. Limitations include the retrospective design and inability to control for therapies stopped between endoscopies.

STUDY TYPE

cohort

SPECIALTY

pediatrics

SUMMARISED BY

AI pipeline

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100% · A

ORIGINAL PAPER

PMC10191577

Incidence of Pediatric Eosinophilic Esophagitis and Characterization of the Stricturing Phenotype in Alberta, Canada

JPGN Reports

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ABSTRACT

Introduction: Limited work has been done to characterize the stricturing pediatric eosinophilic esophagitis (EoE) phenotype. We aimed to determine, in pediatric EoE: the local incidence, the frequency of esophageal stricturing, and the safety of mechanical dilations. Methods: We retrospectively identified all new cases of EoE at our center from 2015 to 2018 using esophageal biopsy reports, EoE clinic lists, and a local OR database of esophageal dilatations. Electronic medical records (EMRs) were reviewed to confirm EoE diagnosis. Clinical data were captured from the outpatient EMR and gastroscopy/pathology reports. Scope adverse event data were captured from multiple sources. The 2016 census data were used to calculate incidence rates. Results: One hundred eighty-five new cases of EoE were diagnosed during the study period. For patients <15 years old living in Edmonton, the incidence over the 4 years was 11.1 cases per 100,000 person years. Eight of 185 (4%) patients had endoscopically confirmed esophageal strictures, 4 of which required mechanical dilation. Eleven of 185 (5.9%) patients had more subtle signs of esophageal narrowing, but no focal strictures. No perforations or episodes of significant bleeding were reported. Pain was reported after 15% of all scopes, including 50% of the 28 scopes with focal strictures. No unexpected admissions or emergency department visits occurred within 72 hours of a gastroscope with esophageal narrowing. Conclusions: Edmonton zone has one of the highest incidences of pediatric EoE reported. In this cohort, 4% had focal esophageal strictures, and 6% had more subtle narrowing. Mechanical dilation of esophageal strictures was associated with no significant adverse events.

CITATION EXPORT

David Burnett, Rabin Persad, Hien Quoc Huynh. Incidence of Pediatric Eosinophilic Esophagitis and Characterization of the Stricturing Phenotype in Alberta, Canada. JPGN Reports. (2021). https://doi.org/10.1097/PG9.0000000000000136

AUTHORS

3 · 2 CENTRES

David Burnett, Rabin Persad, Hien Quoc Huynh

From the *University of Alberta
†University of Saskatchewan.