Individual and combined effects of amoxicillin and carbamazepine to the marine copepod Tigriopus fulvus

Environmental Science and Pollution Research International · 9 authors, 5 centres

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TL;DR

Acute tests (96 h) showed no lethal effects, with LC50 values >100 mg/L for both compounds.

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Acute tests (96 h) showed no lethal effects, with LC50 values >100 mg/L for both compounds. Chronic exposure (28 days) revealed that survival was not affected, but development and reproduction were significantly impaired. Reproduction endpoints were also impacted; for example, treatments at the highest concentrations produced aborted eggs, and the mixture at concentrations around 1 µg/L resulted in decreased reproduction.

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other

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preclinical research

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ORIGINAL PAPER

PMC10167106

Individual and combined effects of amoxicillin and carbamazepine to the marine copepod Tigriopus fulvus

Environmental Science and Pollution Research International

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ABSTRACT

Abstract Pharmaceuticals can be considered a global threat to aquatic ecosystems due to their pseudo-persistence and their potential toxicity towards non-target species. Amoxicillin (AMX) and carbamazepine (CBZ) and their mixture (1:1) were investigated on the marine copepod Tigriopus fulvus (Fischer, 1860) considering both acute and chronic endpoints. While acute and chronic exposure did not directly affect survival, reproductive endpoints were affected like the mean egg hatching time that was significantly longer than the negative control for treatments with AMX (0.789 ± 0.079 μg/L), CBZ (8.88 ± 0.89 μg/L), and AMX and CMZ as a mixture (1.03 ± 0.10 μg/L and 0.941 ± 0.094 μg/L), in that order. Supplementary Information The online version contains supplementary material available at 10.1007/s11356-023-26498-0. Keywords: Amoxicillin, Carbamazepine, Mixture, Tigriopus fulvus , Acute and chronic toxicity

CITATION EXPORT

Ermelinda Prato, Francesca Biandolino, Asia Grattagliano et al.. Individual and combined effects of amoxicillin and carbamazepine to the marine copepod Tigriopus fulvus. Environmental Science and Pollution Research International. (2023). https://doi.org/10.1007/s11356-023-26498-0

AUTHORS

9 · 5 CENTRES

Ermelinda Prato, Francesca Biandolino, Asia Grattagliano, Andrea Ruscito, Giusy Lofrano, Giovanni Libralato, Marco Trifuoggi, Luisa Albarano, Isabella Parlapiano

1National Research Council, Water Research Institute (IRSA-CNR), Via Roma, 3, 74123 Taranto, Italy
2Department of Chemical Sciences and Technologies, University of Rome “Tor Vergata”, Via Della Ricerca Scientifica, 1 – 00133 Rome, Italy
3Università degli Studi di Roma Foro Italico, Piazza Lauro De Bosis, 15, 00135 Rome, Italy
4Department of Biology, University of Naples Federico II, Via Vicinale Cupa Cintia 26, 80126 Naples, Italy
5Department of Chemical Sciences, University of Naples Federico II, Via Vicinale Cupa Cintia 26, 80126 Naples, Italy