This cross-sectional study analyzed data from 94,114 individuals in the Brazilian National Health Survey to compare cardiovascular disease (CVD) risk factors between slum and non-slum populations. After adjusting for socioeconomic factors, slum inhabitants had a higher prevalence of several behavioral risk factors, including low fruit and vegetable consumption, heavy alcohol consumption, and physical inactivity, but no difference in doctor-diagnosed metabolic risk factors or CVD.