Frontiers in Medicine · 3 authors, 1 centre
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This narrative review discusses the inflammatory pathways (e.g., MAPK, NF-κB) involved in dry eye disease and evaluates various anti-inflammatory treatments, such as cyclosporine, corticosteroids, and antibiotics, used in clinical management.
This narrative review examines the inflammatory mechanisms underlying dry eye, a multifactorial ocular surface disease. It describes how conditions like rheumatic diseases, diabetes, and contact lens use activate inflammatory pathways (e.g., MAPK, NF-κB), promoting immune cell activation and cytokine release. The authors conclude that treatment should be multifaceted, combining anti-inflammatory drugs with artificial tears, but note a lack of extensive clinical trials for some newer agents.
