Influence of CReatine supplementation on mUScle mass and strength after stroke (ICaRUS Stroke Trial): study protocol for a randomized controlled trial
Trials · 19 authors, 4 centres
AI SUMMARY
FIDELITY 100%
POPULATIONIndividuals with ischemic stroke in the acute phase who are hospitalized.
INTERVENTION10g of creatine supplementation twice a day for 7 days, plus powdered milk protein serum isolate and daily physiotherapy.
COMPARISON10g of placebo (maltodextrin) twice a day for 7 days, plus powdered milk protein serum isolate and daily physiotherapy.
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This is a protocol for a randomized, double-blind trial that will test whether creatine supplementation, alongside protein and physiotherapy, can improve muscle mass, strength, and functional capacity in hospitalized patients with acute ischemic stroke compared to placebo.
Full summary
827 CHARS
The ICaRUS Stroke Trial is a planned randomized, double-blind, unicenter study evaluating creatine supplementation for 30 hospitalized patients with acute ischemic stroke. The intervention group will receive 10g of creatine twice daily for 7 days, while the control group receives a placebo; both groups will also receive protein supplementation to 1.5g/kg/day and standard physiotherapy. Primary outcomes measured at baseline and day 7 include functional capacity (Modified Rankin Scale, Timed Up and Go test), muscle strength (handgrip strength, chair stand test), and muscle mass (ultrasonography, bioimpedance, D3-methylhistidine). A 90-day follow-up will assess functional capacity, strength, mortality, and quality of life. The authors note the small sample size is a limitation but aim to provide data for future trials.
PICO
PPOPULATION
Individuals with ischemic stroke in the acute phase who are hospitalized.
IINTERVENTION
10g of creatine supplementation twice a day for 7 days, plus powdered milk protein serum isolate and daily physiotherapy.
OOUTCOME
Primary outcomes are functional capacity, strength, and changes in muscle mass after the 7-day intervention, with follow-up at 90 days for functional capacity, muscle strength, mortality, and quality of life.
