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TL;DR
Rats exposed to white LED light for 28 days showed impaired spatial learning and memory along with structural neurodegeneration of primary visual cortex layer 5 pyramidal neurons.
International Ophthalmology · 8 authors, 5 centres
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Rats exposed to white LED light for 28 days showed impaired spatial learning and memory along with structural neurodegeneration of primary visual cortex layer 5 pyramidal neurons.
The light exposure group demonstrated impaired spatial learning and memory on behavioral assessment. Golgi-stained structural analysis revealed neurodegeneration characterized by shortening of apical and basal dendrites of V1L5PNs at all distances from the soma. Two types of blue-light-blocking lenses (CP and DB) demonstrated partial protective efficacy by improving spatial learning, memory, and neuronal structure compared to the light exposure group. The authors note that the 28-day exposure period was short and that retinal structural assessment was lacking, which could provide insight into the pathway leading to visual cortex neuronal degeneration.