INFRAFRONTIER: mouse model resources for modelling human diseases

Mammalian Genome · 9 authors, 3 centres

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TL;DR

This paper describes INFRAFRONTIER, a public database and repository for archiving and distributing genetically engineered mouse strains used to model human diseases.

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This paper describes the INFRAFRONTIER infrastructure, a public repository for archiving and distributing genetically engineered mouse (Mus musculus) strains used to model human diseases. The INFRAFRONTIER database stores and enriches strain data with unique EMMA identifiers, standardized nomenclature, genetic characteristics, phenotypic descriptions, and disease associations. Data is sourced from the scientific community and large-scale projects like the International Mouse Phenotyping Consortium (IMPC), with automated curation using resources from Mouse Genome Informatics (MGI). The resource offers public access to integrated strain data and dedicated disease model portals, including resources for rare diseases and cancer. The paper outlines the repository's services, its connections to other databases like IMSR and IMPC, and its participation in European projects like EJP-RD, ISIDORe, and canSERV.

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other

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preclinical research

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100% · A

ORIGINAL PAPER

PMC10382402

INFRAFRONTIER: mouse model resources for modelling human diseases

Mammalian Genome

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ABSTRACT

Over the last decade, INFRAFRONTIER has positioned itself as a world-class Research Infrastructure for the generation, phenotyping, archiving, and distribution of mouse models in Europe. The INFRAFRONTIER network consists of 22 partners from 15 countries, and is continuously enhancing and broadening its portfolio of resources and services that are offered to the research community on a non-profit basis. By bringing together European rodent model expertise and providing valuable disease model services to the biomedical research community, INFRAFRONTIER strives to push the accessibility of cutting-edge human disease modelling technologies across the European research landscape. This article highlights the latest INFRAFRONTIER developments and informs the research community about its extensively utilised services, resources, and technical developments, specifically the intricacies of the INFRAFRONTIER database, use of Curated Disease Models, overview of the INFRAFRONTIER Cancer and Rare Disease resources, and information about its main state-of-the-art services. Graphical abstract

CITATION EXPORT

Asrar Ali Khan, Gema Valera Vazquez, Montse Gustems et al.. INFRAFRONTIER: mouse model resources for modelling human diseases. Mammalian Genome. (2023). https://doi.org/10.1007/s00335-023-10010-7

AUTHORS

9 · 3 CENTRES

Asrar Ali Khan, Gema Valera Vazquez, Montse Gustems, Rafaele Matteoni, Fei Song, Philipp Gormanns, Sabine Fessele, Michael Raess, Martin Hrabĕ de Angelis

1grid.474101.7INFRAFRONTIER GmbH, Neuherberg, Germany
2grid.5326.20000 0001 1940 4177Institute of Biochemistry and Cell Biology, Italian National Research Council (CNR), Monterotondo, Rome Italy
3grid.4567.00000 0004 0483 2525Institute of Experimental Genetics, Helmholtz Zentrum München (HMGU-IEG), Neuherberg, Germany