Materials · 4 authors, 2 centres
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This narrative review surveys recent preclinical research on nanocellulose materials, focusing on their preparation and applications in wound dressing, tissue engineering, and drug delivery. It concludes that nanocellulose shows great potential for biomedical use but requires more biocompatibility and scalability research.
This narrative review synthesizes recent literature on nanocellulose (NC) materials, specifically cellulose nanocrystals (CNCs), cellulose nanofibers (CNFs), and bacterial nanocellulose (BNC). It details their preparation via top-down and bottom-up methods and discusses their morphological, mechanical, and biological properties. The review highlights applications in wound dressing, tissue engineering, and drug delivery, drawing from studies primarily from the last three years. Central findings are based on laboratory material characterization and animal-model studies, demonstrating NC's versatility in creating hydrogels, films, and bioinks. Limitations include a need for more thorough in vivo biocompatibility studies, challenges in controlling swelling behavior and mechanical strength, and difficulties in comparing studies due to variable preparation methods. The review implies significant potential for NC-based materials in advancing biomedical technology but emphasizes the need to bridge the gap from lab-scale to commercial production.
