SEARCHCOHORTneurology, endocrinology

cohort·neurology, endocrinology, psychiatry, epidemiology, geriatrics·PMC10231438

Insulin resistance, age and depression’s impact on cognition in middle-aged adults from the PREVENT cohort

BMJ Mental Health · 9 authors, 3 centres

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TL;DR

This cross-sectional study of 665 middle-aged adults found that insulin resistance predicts executive dysfunction only in older middle-aged individuals (aged 50-60), while it predicts depressive symptoms in both younger and older groups.

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Central results showed that higher insulin resistance predicted poorer executive function only in the older age group (50-60 years), while higher insulin resistance predicted higher depressive scores in both younger (40-49) and older age groups. Additionally, higher depressive scores predicted poorer performance on a visuospatial memory task (4 Mountains Test) only in the older age group.

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cohort

SPECIALTY

neurology

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ORIGINAL PAPER

PMC10231438

Insulin resistance, age and depression’s impact on cognition in middle-aged adults from the PREVENT cohort

BMJ Mental Health

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ABSTRACT

Background Alzheimer’s disease (AD), type 2 diabetes mellitus (characterised by insulin resistance) and depression are significant challenges facing public health. Research has demonstrated common comorbidities among these three conditions, typically focusing on two of them at a time. Objective The goal of this study, however, was to assess the inter-relationships between the three conditions, focusing on mid-life (defined as age 40–59) risk before the emergence of dementia caused by AD. Methods In the current study, we used cross-sectional data from 665 participants from the cohort study, PREVENT. Findings Using structural equation modelling, we showed that (1) insulin resistance predicts executive dysfunction in older but not younger adults in mid-life, that (2) insulin resistance predicts self-reported depression in both older and younger middle-aged adults and that (3) depression predicts deficits in visuospatial memory in older but not younger adults in mid-life. Conclusions Together, we demonstrate the inter-relations between three common non-communicable diseases in middle-aged adults. Clinical implications We emphasise the need for combined interventions and the use of resources to help adults in mid-life to modify risk factors for cognitive impairment, such as depression and diabetes.

CITATION EXPORT

Sarah D Bauermeister, Michael Ben Yehuda, Graham Reid et al.. Insulin resistance, age and depression’s impact on cognition in middle-aged adults from the PREVENT cohort. BMJ Mental Health. (2023). https://doi.org/10.1136/bmjment-2023-300665

AUTHORS

9 · 3 CENTRES

Sarah D Bauermeister, Michael Ben Yehuda, Graham Reid, Gregory Howgego, Karen Ritchie, Tam Watermeyer, Sarah Gregory, Graciela Muniz Terrera, Ivan Koychev

1 Department of Psychiatry, Medical Sciences Division, University of Oxford, Oxford, UK
2 INSERM, Institut des Neurosciences de Montpellier, Montpellier, France
3 Edinburgh Dementia Prevention, The University of Edinburgh Centre for Clinical Brain Sciences, Edinburgh, UK