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TL;DR
Using APP-KI and APP/IR-dKI mice at 4 months of age, the authors examined whether insulin resistance accelerates early Alzheimer's-related changes.
Aging Cell · 8 authors, 7 centres
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Using APP-KI and APP/IR-dKI mice at 4 months of age, the authors examined whether insulin resistance accelerates early Alzheimer's-related changes.
Using APP-KI and APP/IR-dKI mice at 4 months of age, the authors examined whether insulin resistance accelerates early Alzheimer's-related changes. APP/IR-dKI mice, which carry the P1195L insulin receptor knock-in alongside the APP knock-in, exhibited insulin resistance features (glucose intolerance, hyperinsulinemia) with normal fasting glucose but exaggerated postprandial glucose elevation. In novel object recognition and novel place preference tests, APP-KI mice showed no apparent impairment, whereas APP/IR-dKI mice exhibited obvious cognitive dysfunction. APP/IR-dKI mice did not show accelerated amyloid-beta burden compared with APP-KI mice.