Integrated Omics Approach to Discover Differences in the Metabolism of a New Tibetan Desmodesmus sp. in Two Types of Sewage Treatments

Metabolites · 8 authors, 2 centres

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TL;DR

This study used integrated transcriptomic and metabolomic analysis to compare the molecular responses of a Tibetan microalga, Desmodesmus sp., when treating municipal versus industrial sewage.

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This study employed an integrated omics approach (transcriptomics and metabolomics) to investigate the metabolic differences in a Tibetan Desmodesmus sp. microalga cultivated in municipal (YH_3) and industrial (YH_4) sewage. The analysis revealed that both treatments enriched pathways like ribosome, photosynthesis, and proteasome. The findings provide theoretical support for understanding microalgal adaptation to different wastewater stresses.

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other

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biomedical research

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ORIGINAL PAPER

PMC10058882

Integrated Omics Approach to Discover Differences in the Metabolism of a New Tibetan Desmodesmus sp. in Two Types of Sewage Treatments

Metabolites

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ABSTRACT

Microalgae are now widely applied in municipal (YH_3) and industrial sewage (YH_4) treatments. Through integrated omics analysis, we studied the similarities and differences at the molecular level between the two different types of sewage treatment processes. The most significantly enriched gene ontology (GO) terms in both types of sewage treatments were the ribosome, photosynthesis, and proteasome pathways. The results show that the pathways of differentially expressed genes (DEGs) and differentially accumulated metabolites (DAMs) were enriched for photosynthesis, glyoxylate and dicarboxylate metabolism, and carbon fixation in photosynthetic organisms. Considering YH_3 vs. YH_4, the metabolism of citrate, sedoheptulose-7P, and succinate was significantly upregulated. In addition, the results showed that the pathways of DEGs and DAMs were enriched in terms of amino acid metabolism and carotenoid biosynthesis in YH_4 vs. YH_3. The metabolism of S-Adenosyl-L-homocysteine was significantly downregulated, 2-oxobutanoate was significantly upregulated and downregulated, and the metabolism of abscisic acid glucose ester (ABA-GE) was also significantly upregulated. Overall, the results of this paper will help to improve the basic knowledge of the molecular response of microalgae to sewage treatments, and help design a response strategy based on microalgae for complex, mixed sewage treatments.

CITATION EXPORT

Jinhu Wang, Junyu Chen, Dongdong Zhang et al.. Integrated Omics Approach to Discover Differences in the Metabolism of a New Tibetan Desmodesmus sp. in Two Types of Sewage Treatments. Metabolites. (2023). https://doi.org/10.3390/metabo13030388

AUTHORS

8 · 2 CENTRES

Jinhu Wang, Junyu Chen, Dongdong Zhang, Xiaomei Cui, Jinna Zhou, Jing Li, Yanli Wei, Duo Bu

1College of Ecological Environment, Tibet University, 10 East Zangda Road, Lhasa 850000, China
2Hunan Eco-Geological Survey and Monitoring Institute, 256 Shaoshan North Road, Yuhua District, Changsha 410000, China

EDITOR / REVIEWER

Phillipe Soucaille