SEARCHCROSS-SECTIONALcardiology, rheumatology

cross-sectional·cardiology, rheumatology, nutrition, epidemiology, public health·PMC10067192

Interaction between rheumatoid arthritis and mediterranean diet on the risk of cardiovascular disease for the middle aged and elderly from National Health and Nutrition Examination Survey (NHANES)

BMC Public Health · 5 authors, 1 centre

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TL;DR

This cross-sectional study analyzed NHANES data to find that self-reported rheumatoid arthritis and low adherence to a Mediterranean diet were individually associated with increased odds of self-reported cardiovascular disease, and their coexistence showed a synergistic interaction.

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This cross-sectional study used data from 3,352 participants in the NHANES 2005–2010 database to examine the relationship and interaction between rheumatoid arthritis (RA) and adherence to the Mediterranean diet (MD) on the risk of cardiovascular disease (CVD). Both RA and low MD adherence were assessed via self-report, and their association with self-reported CVD was analyzed using weighted multivariate logistic regression. The results showed that RA was associated with a 2.65-fold increased odds of CVD, and low MD adherence was associated with a 1.67-fold increased odds in adjusted models. Crucially, the study found both additive and multiplicative interactions between RA and low MD adherence on CVD risk, suggesting a synergistic effect. Limitations include the cross-sectional design, which cannot establish causality, and reliance on self-reported data for key exposures and outcomes.

STUDY TYPE

cross-sectional

SPECIALTY

cardiology

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100% · A

ORIGINAL PAPER

PMC10067192

Interaction between rheumatoid arthritis and mediterranean diet on the risk of cardiovascular disease for the middle aged and elderly from National Health and Nutrition Examination Survey (NHANES)

BMC Public Health

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ABSTRACT

Background Cardiovascular diseases (CVD) occurrence were associated with rheumatoid arthritis (RA) and Mediterranean diet (MD), but few studies have been conducted to explore the combined effect. This study was to outline the relationship of coexistence of RA and MD on the risk of CVD based on the National Health and Nutrition Examination Survey (NHANES) database. Methods The data of this cross-sectional study was from the NHANES 2005–2010. The definition of CVD and RA was based on the self-reported questions, respectively; and the alternate MD Index assessed all participants’ adherence to the MD. Weighted multivariate logistic regression was adopted to explore the relationship of RA, MD on the risk of CVD, and coexistence effect of RA and MD. The additive interaction was evaluated by the relative excess risk due to interaction (RERI), attributable proportion (AP) and the synergy index (SI). The multiplicative interaction was evaluated by odds ratio (OR) and 95% confidence interval (CI) of product-term. Results A total of 3,352 participants from NHANES database who were divided into CVD group (n = 385) and non-CVD group (n = 2,967). The result indicated that RA (Model 1: OR = 3.98, 95%CI: 2.76–5.73; Model 2: OR = 2.65, 95%CI: 1.69–4.16) and low adherence to the MD (Model 1: OR = 1.82, 95%CI: 1.13–2.93; Model 2: OR = 1.67, 95%CI:1.01–2.77) was associated with an increased risk of CVD, respectively. Additionally, we observed the additive (RERI = 4.76, 95% CI: 0.52-9.00; AP = 0.74, 95% CI: 0.54–0.95; SI = 8.21, 95% CI: 1.48–45.51) and multiplicative (OR = 3.63, 95% CI: 1.44–9.15) interaction of RA and low adherence to the MD on the risk of CVD. Conclusion RA and MD were associated with CVD occurrence, respectively, and there may be an interaction between RA and MD for the development of CVD. Supplementary Information The online version contains supplementary material available at 10.1186/s12889-023-15478-1.

CITATION EXPORT

Yuwei Zhan, Zhou Yang, Ying Liu et al.. Interaction between rheumatoid arthritis and mediterranean diet on the risk of cardiovascular disease for the middle aged and elderly from National Health and Nutrition Examination Survey (NHANES). BMC Public Health. (2023). https://doi.org/10.1186/s12889-023-15478-1

AUTHORS

5 · 1 CENTRES

Yuwei Zhan, Zhou Yang, Ying Liu, Feng Zhan, Shudian Lin

grid.459560.b0000 0004 1764 5606Rheumatology Department, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, No.19 Xiuhua Road, Xiuying District, Haikou, Hainan Province 570311 P.R. China