SEARCHSYSTEMATIC_REVIEWemergency medicine, pediatrics

systematic_review·emergency medicine, pediatrics, geriatrics, systematic review, clinical trial·PMC10095441

Intranasal Fentanyl for Acute Pain Management in Children, Adults and Elderly Patients in the Prehospital Emergency Service and in the Emergency Department: A Systematic Review

Journal of Clinical Medicine · 7 authors, 7 centres

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FIDELITY 100%

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AGENT 01 · STRUCTURED SUMMARY

TRACE TO SOURCE

“

TL;DR

Minor adverse events, such as nausea, dizziness, and unpleasant taste, were commonly reported but typically did not require intervention.

Full summary

335 CHARS

Minor adverse events, such as nausea, dizziness, and unpleasant taste, were commonly reported but typically did not require intervention. The review noted variability in study quality, with some RCTs rated as having a high risk of bias, and highlighted a lack of data specifically for elderly patients in emergency department settings.

STUDY TYPE

systematic_review

SPECIALTY

emergency medicine

SUMMARISED BY

AI pipeline

FIDELITY CHECK

100% · A

ORIGINAL PAPER

PMC10095441

Intranasal Fentanyl for Acute Pain Management in Children, Adults and Elderly Patients in the Prehospital Emergency Service and in the Emergency Department: A Systematic Review

Journal of Clinical Medicine

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ABSTRACT

Abstract This systematic review examined the efficacy and safety of intranasal fentanyl (INF) for acute pain treatment in children, adults, and the elderly in prehospital emergency services (PHES) and emergency departments (ED). ClinicalTrials.gov, LILACS, PubMed, SCOPUS, EMBASE, Google Scholar and Cochrane databases were consulted until 31 December 2022. A total of 23 studies were included: 18 in children (1 PHES, 17 ED), 5 in adults (1 PHES, 4 ED) and 1 in older people (1 PHES subgroup analysis). In children, INF was effective in both settings and as effective as the comparator drugs, with no differences in adverse events (AEs); one randomised controlled trial (RCT) showed that INF was more effective than the comparator drugs. In adults, one study demonstrated the efficacy of INF in the PHES setting, one study demonstrated the efficacy of INF in the ED setting, two RCTs showed INF to be less effective than the comparator drugs and one RCT showed INF to be as effective as the comparator, with no difference in AEs reported. In older people, one study showed effective pain relief and no AEs. In summary, INF appears to be effective and safe in children and adults in PHES and ED. More high-quality studies are needed, especially in PHES and older people. Keywords: intranasal administration, fentanyl, pain, emergency department, prehospital emergency service

CITATION EXPORT

Sossio Serra, Michele Domenico Spampinato, Alessandro Riccardi et al.. Intranasal Fentanyl for Acute Pain Management in Children, Adults and Elderly Patients in the Prehospital Emergency Service and in the Emergency Department: A Systematic Review. Journal of Clinical Medicine. (2023). https://doi.org/10.3390/jcm12072609

AUTHORS

7 · 7 CENTRES

Sossio Serra, Michele Domenico Spampinato, Alessandro Riccardi, Mario Guarino, Rita Pavasini, Andrea Fabbri, Fabio De Iaco

1Emergency Department, Maurizio Bufalini Hospital, 47521 Cesena, Italy
2Department of Translational Medicine and for Romagna, University of Ferrara, 44124 Ferrara, Italy
3Pronto Soccorso Ospedale di Imperia, 18100 Imperia, Italy
4UOC MEU Ospedale CTO- AORN dei Colli Napoli, 80131 Naples, Italy
5UO Cardiologia, Azienda Ospedaliero Universitaria di Ferrara, 44124 Ferrara, Italy
6Emergency Department, AUSL Romagna, Presidio Ospedaliero Morgagni-Pierantoni, 47121 Forlì, Italy
7Struttura Complessa di Medicina di Emergenza Urgenza Ospedale Maria Vittoria, ASL Città di Torino, 10144 Torino, Italy