This narrative review analyzed existing literature to identify childhood and adolescent factors, such as diet, exercise, and body mass index, that may be associated with the development of benign breast disease and breast cancer later in adulthood.
Children · 6 authors, 1 centre
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This narrative review analyzed existing literature to identify childhood and adolescent factors, such as diet, exercise, and body mass index, that may be associated with the development of benign breast disease and breast cancer later in adulthood.
The review concludes that numerous risk factors, whose influence begins in childhood and adolescence, are associated with these outcomes. Associations noted include higher meat and alcohol intake with increased cancer risk, higher fiber intake with lower proliferative BBD risk, physical activity with reduced cancer risk, and an inverse relationship for premenopausal cancer with higher body mass index. Exposure to chest radiation during youth is linked to increased cancer risk. Limitations include significant heterogeneity among included studies, potential for recall and ascertainment bias, lack of complete follow-up, and exclusion of non-English papers.