SEARCHCROSS-SECTIONALnutrition, dietetics

cross-sectional·nutrition, dietetics, clinical nutrition, endocrinology, epidemiology·PMC10521509

Investigation of the association between habitual dietary FODMAP intake, metabolic parameters, glycemic status, and anthropometric features among apparently healthy overweight and obese individuals

BMC Endocrine Disorders · 8 authors, 7 centres

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A cross-sectional study analyzed 347 overweight and obese adults from outpatient clinics in Iran.

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A cross-sectional study analyzed 347 overweight and obese adults from outpatient clinics in Iran. Dietary FODMAP intake was assessed using a validated 168-item Food Frequency Questionnaire, and participants were categorized into high, moderate, and low FODMAP groups based on intake tertiles. Anthropometric measures, body composition, and biochemical parameters (lipids, glucose, insulin, HOMA-IR, QUICKI) were measured. Results showed that in the high FODMAP group, individuals in the highest tertile had significantly higher systolic blood pressure compared to the lowest tertile in crude and age/sex-adjusted models. Additionally, higher serum insulin, HOMA-IR, and lower QUICKI were observed in the second tertile of the high FODMAP group. In the moderate FODMAP group, higher tertiles were associated with lower waist-to-hip ratio and higher fat-free mass.

STUDY TYPE

cross-sectional

SPECIALTY

nutrition

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ORIGINAL PAPER

PMC10521509

Investigation of the association between habitual dietary FODMAP intake, metabolic parameters, glycemic status, and anthropometric features among apparently healthy overweight and obese individuals

BMC Endocrine Disorders

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ABSTRACT

Abstract Background The predisposition of humans to metabolic syndrome is affected by many factors, including diet and lifestyle. Fermentable oligosaccharides, disaccharides, monosaccharides, and polyols (FODMAPs) are a set of carbohydrates that are fermented by gut microbiota. In animal studies, supplementation with FODMAP-rich diets as prebiotics can alter body composition and gut microbiota. This study evaluates any relationship between FODMAP and metabolic syndrome risk factors among adults with metabolic syndrome in Iran. Methods This cross-sectional study is based on sociodemographic information from 347 overweight and obese participants selected from outpatient clinics through public declaration. Participants body composition and anthropometric measures were also determined. A validated Food Frequency Questionnaire (FFQ) with 168 questions was used to collect dietary data. Biochemical parameters, including serum total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), fasting serum glucose (FSG), and insulin levels, were determined by enzymatic methods. In addition, the Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) and Quantitative Insulin Sensitivity Check Index (QUICKI) were calculated. Results In moderate FODMAP and low FODMAP groups, lower waist-to-hip ratio (WHR) and higher fat-free mass (FFM) were achieved in higher tertiles. In high FODMAP groups, higher systolic blood pressure (SBP) was shown in the higher tertile ( P < 0.05). Higher insulin, HOMA-IR, and lower QUICKI in the second tertile of the high FODMAP group were also observed. Conclusion Findings of this study highlight the potential role of FODMAP in managing metabolic syndrome and open a new field of research. Keywords: FODMAP diet, Metabolic syndrome, Dyslipidemia, Obesity

CITATION EXPORT

Reyhaneh Mokhtari Hemami, Amir Shakarami, Abnoos Mokhtari Ardekani et al.. Investigation of the association between habitual dietary FODMAP intake, metabolic parameters, glycemic status, and anthropometric features among apparently healthy overweight and obese individuals. BMC Endocrine Disorders. (2023). https://doi.org/10.1186/s12902-023-01458-4

AUTHORS

8 · 7 CENTRES

Reyhaneh Mokhtari Hemami, Amir Shakarami, Abnoos Mokhtari Ardekani, Sara Aghaii, Dorna Makarem, Negin Nikrad, Mahdieh Abbasalizad Farhangi, Mohammad Sadegh Pour Abbasi

1Tabriz Health Services Management Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
2Department of Cardiovascular Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran
3Endocrinology and Metabolism Research Center, Institute of Basic and Clinical Physiology Science, & Physiology Research Center, Kerman University of Medical Sciences, Kerman, Iran
4Faculty of Medical Sciences, Tehran University of Medical Sciences, Tehran, Iran
5Escuela Tecnica Superior de Ingenieros de Telecomunicacion Politecnica de Madrid, Madrid, Spain
6Department of Community Nutrition, Faculty of Nutrition, Tabriz University of Medical Sciences, Tabriz, Iran
7Department of Cardiovascular Surgery, Kashan University of Medical Sciences and Health Services, Kashan, Iran