SEARCHNARRATIVE_REVIEWpsychiatry, immunology

narrative_review·psychiatry, immunology, biomedical research, neurology, public health·PMC10601302

Invited Expert Opinion- Bioinformatic and Limitation Directives to Help Adopt Genetic Addiction Risk Screening and Identify Preaddictive Reward Dysregulation: Required Analytic Evidence to Induce Dopamine Homeostatsis

Medical research archives · 25 authors, 32 centres

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The central argument is that achieving dopamine homeostasis, rather than inhibition, could be a goal for treating addictions, and systems biology approaches may aid in early detection.

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This invited expert opinion and narrative review discusses the limitations of current medication-assisted treatments (MAT) for addiction, which primarily inhibit dopamine, and advocates for a shift toward restoring dopamine homeostasis. The paper outlines a framework for necessary analytic evidence to support these screening methods, referencing a family genotypic study (N=32) as an example. Implications are futuristic, suggesting a disruptive technology approach to addiction treatment and screening.

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narrative_review

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psychiatry

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ORIGINAL PAPER

PMC10601302

Invited Expert Opinion- Bioinformatic and Limitation Directives to Help Adopt Genetic Addiction Risk Screening and Identify Preaddictive Reward Dysregulation: Required Analytic Evidence to Induce Dopamine Homeostatsis

Medical research archives

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CITATION EXPORT

Kenneth Blum, Mark S Gold, Jean Lud Cadet et al.. Invited Expert Opinion- Bioinformatic and Limitation Directives to Help Adopt Genetic Addiction Risk Screening and Identify Preaddictive Reward Dysregulation: Required Analytic Evidence to Induce Dopamine Homeostatsis. Medical research archives. (2023). https://doi.org/10.18103/mra.v11i8.4211

AUTHORS

25 · 32 CENTRES

Kenneth Blum, Mark S Gold, Jean Lud Cadet, Marjorie C Gondre-Lewis, Thomas McLaughlin, Eric R Braverman, Igor Elman, B Paul Carney, Rene Cortese, Tomilowo Abijo, Debasis Bagchi, John Giordano, Catherine A Dennen, David Baron, Panayotis K Thanos, Diwanshu Soni, Milan T Makale, Miles Makale, Kevin T Murphy, Nicole Jafari, Keerthy Sunder, Foojan Zeine, Mauro Ceccanti, Abdalla Bowirrat, Rajendra D Badgaiyan

1.The Kenneth Blum Behavioral & Neurogenetic Institute, Austin, TX., USA
2.Division of Addiction Research & Education, Center for Sports, Exercise & Psychiatry, Western University Health Sciences, Pomona, CA., USA
3.Institute of Psychology, ELTE Eötvös Loránd University, Budapest, Hungary
4.Department of Psychiatry, School of Medicine, University of Vermont, Burlington, VT.,USA
5.Department of Psychiatry, Wright State University Boonshoft School of Medicine and Dayton VA Medical Centre, Dayton, OH, USA
6.Division of Nutrigenomics Research, TranspliceGen Therapeutics, Inc., Austin, Tx., 78701, USA
7.Department of Psychiatry, Washington University School of Medicine, St. Louis, MO., USA
8.Molecular Neuropsychiatry Research Branch, National Institute on Drug Abuse, National Institutes of Health, Bethesda, MD., USA
9.Neuropsychopharmacology Laboratory, Department of Anatomy, Howard University College of Medicine, Washington, DC., USA
10.Center for Pain and the Brain (P.A.I.N Group), Department of Anesthesiology, Critical Care & Pain Medicine, Boston Children’s Hospital, Boston, MA., USA
11.Division Pediatric Neurology, University of Missouri, School of Medicine, Columbia, MO., USA
12.Department of Child Health – Child Health Research Institute, & Department of Obstetrics, Gynecology and Women’s Health School of Medicine, University of Missouri, MO., USA
13.Department of Nutrigenomic Research, Victory Nutrition International, Inc., Bonita Springs, FL, USA
14.Department of Pharmaceutical Sciences, Texas Southern University College of Pharmacy and Health Sciences, Houston, TX, USA
15.Division of Personalized Mental Illness Treatment & Research, Ketamine Infusion Clinics of South Florida, Pompano Beach, Fl., USA
16.Department of Family Medicine, Jefferson Health Northeast, Philadelphia, PA, USA
17.Behavioral Neuropharmacology and Neuroimaging Laboratory on Addictions, Clinical Research Institute on Addictions, Department of Pharmacology and Toxicology, Jacobs School of Medicine and Biosciences, State University of New York at Buffalo, Buffalo, NY 14203, USA
18.Department of Psychology, State University of New York at Buffalo, Buffalo, NY 14203, USA
19.College of Osteopathic Medicine of the Pacific, Western University of Health Sciences, Pomona, CA., USA
20.Department of Radiation Medicine and Applied Sciences, UC San Diego, 3855 Health Sciences Drive, La Jolla, CA 92093-0819, USA
21.Department of Psychology, UC San Diego, Health Sciences Drive, La Jolla, CA, 92093, USA
22.Peak Logic, San Diego, CA., USA
23.Department of Human Development, California State University at long Beach, Long Beach, CA., USA
24.Division of Personalized Medicine, Cross-Cultural Research and Educational Institute, San Clemente, CA., USA
25.Department of Psychiatry, Menifee Global Medical Center, Palm Desert, CA., USA
26.Sunder Foundation, Palm Springs, CA, USA
27.Awareness Integration Institute, San Clemente, CA., USA
28.Department of Health Science, California State University at Long Beach, Long Beach, CA., USA
29.Società Italiana per il Trattamento dell’Alcolismo e le sue Complicanze (SITAC), ASL Roma1, Sapienza University of Rome, Rome, Italy
30.Department of Molecular Biology and Adelson School of Medicine, Ariel University, Ariel, Israel
31.Department of Psychiatry, South Texas Veteran Health Care System, Audie L. Murphy Memorial VA Hospital, Long School of Medicine, University of Texas Medical Center, San Antonio, TX., USA
32.Department of Psychiatry, Mt Sinai University School of Medicine, New York, NY., USA

Kenneth Blum, Mark S Gold, Jean Lud Cadet et al.. Invited Expert Opinion- Bioinformatic and Limitation Directives to Help Adopt Genetic Addiction Risk Screening and Identify Preaddictive Reward Dysregulation: Required Analytic Evidence to Induce Dopamine Homeostatsis. Medical research archives. (2023). https://doi.org/10.18103/mra.v11i8.4211