NPJ Regenerative Medicine · 11 authors, 3 centres
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The study developed a Janus porous polylactic acid (PLA) membrane coated with a metal–phenolic network (MPN) interface. In a rat model, the membrane facilitated periodontal bone defect repair by regulating immune, angiogenic, and osteogenic processes.
The study describes the development of a Janus porous PLA membrane with a metal–phenolic network (MPN) coating for periodontal bone regeneration. The dense side of the membrane acts as a barrier, while the porous side serves as a scaffold. In vitro experiments showed the MPN coating inhibited macrophage pro-inflammatory states, promoted HUVEC angiogenesis, and enhanced hPDLSC osteogenesis. In a rat periodontal bone defect model, the PLAM-MPN membrane facilitated bone defect repair. The authors note the potential immunogenicity of PEG used in processing and suggest exploring alternative pore-forming techniques for future clinical translation. The study demonstrates a surface modification strategy using MPN coatings.
