SEARCHCASE-CONTROLdermatology, oncology

case-control·dermatology, oncology, epidemiology, nutrition, public health·PMC45584

Joint effects of citrus peel use and black tea intake on the risk of squamous cell carcinoma of the skin

BMC Dermatology · 2 authors, 1 centre

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TL;DR

This population-based case-control study found that consuming both citrus peel and hot black tea was associated with a significantly lower risk of skin squamous cell carcinoma compared to consuming neither.

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The study suggests a potential protective effect of citrus peel and strong (hot) black tea, possibly due to bioactive compounds like d-limonene and tea polyphenols, but notes this is a case-control design which cannot establish causation.

STUDY TYPE

case-control

SPECIALTY

dermatology

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100% · A

ORIGINAL PAPER

PMC45584

Joint effects of citrus peel use and black tea intake on the risk of squamous cell carcinoma of the skin

BMC Dermatology

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ABSTRACT

Abstract Background Differences in tea drinking habits and/or citrus peel use are likely to vary by populations and could contribute to the inconsistencies found between studies comparing their consumption and cancer risk. Methods A population-based case-control study was used to evaluate the relationships between citrus peel use and black tea intake and squamous cell carcinoma (SCC) of the skin. Moreover, we assessed the independent and interactive effects of citrus peel and black tea in the development of SCC. Results Hot and iced teas were consumed by 30.7% and 51.8% of the subjects, respectively. Peel consumption was reported by 34.5% of subjects. Controls were more likely than were cases to report citrus peel use (odds ratio (OR) = 0.67) and hot tea intake (OR = 0.79). After adjustment for hot and iced tea intake, the ORs associated with citrus peel use were 0.55 and 0.69, respectively, whereas the corresponding adjusted ORs for hot and iced tea intake after adjustment for citrus peel use were 0.87 and 1.22 respectively. Compared with those who did not consume hot black tea or citrus peel, the adjusted ORs associated with sole consumption of hot black tea or citrus peel were 0.60 and 0.30, respectively. Subjects who reported consumption of both hot black tea and citrus peel had a significant marked decrease (OR= 0.22; 95% CI = 0.10 – 0.51) risk of skin SCC. Conclusion These results indicate that both citrus peel use and strong (hot) black tea have independent potential protective effects in relation to skin SCC.

CITATION EXPORT

Iman A Hakim, Robin B Harris. Joint effects of citrus peel use and black tea intake on the risk of squamous cell carcinoma of the skin. BMC Dermatology. (2001). https://doi.org/10.1186/1471-5945-1-3

AUTHORS

2 · 1 CENTRES

Iman A Hakim, Robin B Harris

1University of Arizona College of Public Health and the Arizona Cancer Center, 1515 N Campbell Ave, Tucson, AZ 85724, USA