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RCT·endocrinology, internal medicine, nutrition, clinical trial, obstetrics and gynecology·PMC10181094

Late, but Not Early, Night Sleep Loss Compromises Neuroendocrine Appetite Regulation and the Desire for Food

Nutrients · 9 authors, 8 centres

AI SUMMARY

FIDELITY 100%

POPULATION15 healthy, normal-weight men (BMI 23.3 ± 0.4 kg/m^2^)

INTERVENTION4 hours of sleep during the second night-half ('late-night sleep loss')

COMPARISON4 hours of sleep during the first night-half ('early-night sleep loss') and 8 hours of regular sleep

This summary was generated by AI from a single paper. It has not been reviewed by a clinician and is not clinical advice. Verify against the source before acting on it.

AGENT 01 · STRUCTURED SUMMARY

TRACE TO SOURCE

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TL;DR

In a randomized crossover study of 15 healthy men, restricting sleep by 4 hours in the second half of the night (late-night sleep loss) increased plasma ghrelin and subjective feelings of hunger and desire for food, whereas restricting sleep in the first half of the night did not.

Full summary

1,085 CHARS

This randomized, balanced, crossover study investigated the impact of sleep loss timing on appetite regulation in 15 healthy, normal-weight men. Participants completed three conditions: 4 hours of sleep in the first half of the night (early-night sleep loss), 4 hours of sleep in the second half of the night (late-night sleep loss), and 8 hours of regular sleep. Plasma ghrelin and leptin were measured from blood samples, and subjective ratings of hunger, appetite, and desire for food were collected. The central result was that late-night sleep loss, but not early-night sleep loss, significantly increased ghrelin levels and feelings of hunger, appetite, and desire for food, while leptin was unaffected by sleep loss timing. Limitations include the small sample size, single-night intervention, and that the findings are specific to healthy, normal-weight men. The results suggest that the timing of sleep restriction, not just its duration, is a critical factor in acute neuroendocrine appetite regulation, highlighting potential metabolic risks of late-night sleep curtailment.

PICO

PPOPULATION

15 healthy, normal-weight men (BMI 23.3 ± 0.4 kg/m^2^)

IINTERVENTION

4 hours of sleep during the second night-half ('late-night sleep loss')

OOUTCOME

Plasma ghrelin and leptin concentrations; visual analogue scale ratings of hunger, appetite, and desire for food

STUDY TYPE

RCT

SPECIALTY

endocrinology

SUMMARISED BY

AI pipeline

FIDELITY CHECK

100% · A

ORIGINAL PAPER

PMC10181094

Late, but Not Early, Night Sleep Loss Compromises Neuroendocrine Appetite Regulation and the Desire for Food

Nutrients

READ THE FULL PAPER

ABSTRACT

Objective: There is evidence that reduced sleep duration increases hunger, appetite, and food intake, leading to metabolic diseases, such as type 2 diabetes and obesity. However, the impact of sleep timing, irrespective of its duration and on the regulation of hunger and appetite, is less clear. We aimed to evaluate the impact of sleep loss during the late vs. early part of the night on the regulation of hunger, appetite, and desire for food. Methods: Fifteen normal-weight ([mean ± SEM] body-mass index: 23.3 ± 0.4 kg/m 2 ) healthy men were studied in a randomized, balanced, crossover design, including two conditions of sleep loss, i.e., 4 h sleep during the first night-half (‘late-night sleep loss’), 4 h sleep during the second night-half (‘early-night sleep loss’), and a control condition with 8h sleep (‘regular sleep’), respectively. Feelings of hunger and appetite were assessed through visual analogue scales, and plasma ghrelin and leptin were measured from blood samples taken before, during, and after night-time sleep. Results: Ghrelin and feelings of hunger and appetite, as well as the desire for food, were increased after ‘late-night sleep loss’, but not ‘early-night sleep loss’, whereas leptin remained unaffected by the timing of sleep loss. Conclusions: Our data indicate that timing of sleep restriction modulates the effects of acute sleep loss on ghrelin and appetite regulation in healthy men. ‘Late-night sleep loss’ might be a risk factor for metabolic diseases, such as obesity and type 2 diabetes. Thereby, our findings highlight the metabolic relevance of chronobiological sleep timing.

CITATION EXPORT

Svenja Meyhöfer, Rodrigo Chamorro, Manfred Hallschmid et al.. Late, but Not Early, Night Sleep Loss Compromises Neuroendocrine Appetite Regulation and the Desire for Food. Nutrients. (2023). https://doi.org/10.3390/nu15092035

AUTHORS

9 · 8 CENTRES

Svenja Meyhöfer, Rodrigo Chamorro, Manfred Hallschmid, Denisa Spyra, Nelli Klinsmann, Bernd Schultes, Hendrik Lehnert, Sebastian M. Meyhöfer, Britta Wilms

1Institute for Endocrinology and Diabetes, University of Lübeck, 23562 Lübeck, Germany
2German Center for Diabetes Research (DZD), 85764 Neuherberg, Germany
3Department of Internal Medicine 1, Endocrinology & Diabetes, University of Lübeck, 23538 Lübeck, Germany
4Center of Brain, Behavior & Metabolism, University of Lübeck, 23562 Lübeck, Germany
5Department of Nutrition, Faculty of Medicine, University of Chile, Santiago 8380453, Chile
6Department of Medical Psychology and Behavioral Neurobiology, University of Tübingen, 72076 Tübingen, Germany
7Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Centre Munich, University of Tübingen (IDM), 72076 Tübingen, Germany
8University of Salzburg, A-5020 Salzburg, Austria

EDITOR / REVIEWER

Albert Lecube, David J. Mela