SEARCHCROSS-SECTIONALpediatrics, public health

cross-sectional·pediatrics, public health, epidemiology, nutrition, micronutrients·PMC10049063

Lead Exposure Can Affect Early Childhood Development and Could Be Aggravated by Stunted Growth: Perspectives from Mexico

International Journal of Environmental Research and Public Health · 10 authors, 8 centres

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TL;DR

A 2018 Mexican cross-sectional household survey (ENSANUT-100K) found that half of children aged 12–59 months had detectable blood lead levels and 15.3% had stunted growth.

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The ENSANUT-100K cross-sectional household survey (March–June 2018) used basic geostatistical areas as primary sampling units and oversampled disadvantaged households, with all estimates weighted. Of 3576 children under 60 months surveyed, 1394 aged 12–59 months had complete language, blood lead, and anthropometric data; 753 aged 36–59 months additionally had ECDI data. Regional language differences were significant (p < 0.001), lowest in the south. The percentage not on-track was higher in the poorest households (p < 0.001).

STUDY TYPE

cross-sectional

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pediatrics

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AI pipeline

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ORIGINAL PAPER

PMC10049063

Lead Exposure Can Affect Early Childhood Development and Could Be Aggravated by Stunted Growth: Perspectives from Mexico

International Journal of Environmental Research and Public Health

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ABSTRACT

Abstract Background: Lead can affect early childhood development (ECD) differentially due to nutritional deficiencies that lead to stunted growth, defined as being at least two standard deviations below the average height-for-age. These deficiencies are more frequent among children living in rural locations or with lower socioeconomic status (SES); however, studies at a population level are scarce worldwide. Early childhood development plays a crucial role in influencing a child’s health and wellbeing throughout life. Therefore, the aim of this study was to analyze how stunted growth can modify the association between lead exposure and ECD in children from disadvantaged communities. Methods: Data were analyzed from the 2018 National Health and Nutrition Survey in localities with fewer than 100,000 inhabitants in Mexico (ENSANUT-100K). Capillary blood lead (BPb) levels were measured using a LeadCare II device and dichotomized as detectable (cutoff point ≥ 3.3 µg/dL) and non-detectable. As a measure of ECD, language development was assessed in n = 1394 children, representing 2,415,000 children aged 12–59 months. To assess the association between lead exposure and language z-scores, a linear model was generated adjusted by age, sex, stunted growth, maternal education, socioeconomic status, area, region (north, center, south), and family care characteristics; afterwards, the model was stratified by stunted growth. Results: Fifty percent of children had detectable BPb and 15.3% had stunted growth. BPb showed a marginal inverse association with language z-scores (β: −0.08, 95% CI: −0.53, 0.36). Children with detectable BPb and stunted growth had significantly lower language z-scores (β: −0.40, 95% CI: −0.71, −0.10) than those without stunted growth (β: −0.15, 95% CI: −0.36, 0.06). Conclusions: Children with stunted growth are more vulnerable to the adverse effects of lead exposure. These results add to previous research calling for action to reduce lead exposure, particularly in children with chronic undernutrition. Keywords: early childhood development, language, lead exposure, stunted growth

CITATION EXPORT

Leonel Córdoba-Gamboa, Ruth Argelia Vázquez-Salas, Martin Romero-Martínez et al.. Lead Exposure Can Affect Early Childhood Development and Could Be Aggravated by Stunted Growth: Perspectives from Mexico. International Journal of Environmental Research and Public Health. (2023). https://doi.org/10.3390/ijerph20065174

AUTHORS

10 · 8 CENTRES

Leonel Córdoba-Gamboa, Ruth Argelia Vázquez-Salas, Martin Romero-Martínez, Alejandra Cantoral, Horacio Riojas-Rodríguez, Sergio Bautista-Arredondo, Luis F Bautista-Arredondo, Filipa de Castro, Marcela Tamayo-Ortiz, Martha María Téllez-Rojo

1Dirección de Salud Ambiental, Centro de Investigación en Salud Poblacional, Instituto Nacional de Salud Pública, Cuernavaca 62100, Morelos, Mexico; [email protected] (L.C.-G.);
2Dirección de Salud Reproductiva, Centro de Investigación en Salud Poblacional, Instituto Nacional de Salud Pública, Ciudad de México 14080, Morelos, Mexico
3Centro de Investigación en Evaluación y Encuestas, Instituto Nacional de Salud Pública, Cuernavaca 62100, Morelos, Mexico
4Departamento de Salud, Universidad Iberoamericana, Ciudad de Mexico 01219, Morelos, Mexico
5Centro de Investigación en Sistemas de Salud, Instituto Nacional de Salud Pública, Cuernavaca 62100, Morelos, Mexico
6Centro de Investigación en Nutrición y Salud, Instituto Nacional de Salud Pública, Cuernavaca 62100, Morelos, Mexico
7Research, Evidence, and Learning, Department of Education and Child Population, Save the Children, 501 Kings Highway East, Suite 400, Fairfield, CT 06825, USA
8Unidad de Investigación de Salud en el Trabajo, Instituto Mexicano del Seguro Social, Ciudad de México 6720, Morelos, Mexico