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TL;DR
This retrospective cohort study analyzed 77 patients with sinonasal malignancies and found that long-term post-treatment complications occurred in 53% of patients, with radiation therapy being the only significant predictor.
Acta Otorhinolaryngologica Italica · 7 authors, 3 centres
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This retrospective cohort study analyzed 77 patients with sinonasal malignancies and found that long-term post-treatment complications occurred in 53% of patients, with radiation therapy being the only significant predictor.
The study retrospectively analyzed 77 patients treated for sinonasal malignancies at a tertiary center between 2001 and 2018 to evaluate long-term (>6 months) post-treatment complications. The primary outcome was the occurrence of long-term complications. Results showed that 41 patients (53%) developed complications, most commonly sinonasal (29%) and orbital/ocular (23%). A multivariate analysis identified irradiation as the sole significant predictor of long-term complications (p=0.001). Radiation therapy for disease recurrence was associated with a higher complication rate (56% vs 11%; p=0.04). The study's limitations include its retrospective design, small sample size, and histologic and treatment heterogeneity. The findings underscore the substantial long-term morbidity of sinonasal malignancy management and the dominant role of radiation therapy.