The Journal of Clinical Endocrinology and Metabolism · 5 authors, 9 centres
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This mini-review summarizes published original data on metabolic and bariatric surgery outcomes in adolescents beyond 2 years postoperatively. It finds that weight loss and cardiometabolic improvements are sustained at medium to long-term follow-up, while psychosocial benefits may be more transient.
Studies included prospective cohorts such as Teen-LABS, AMOS, and FABS5+, as well as large retrospective series. After a mean of 8 years, the FABS5+ study reported 29% total body weight loss. Sleeve gastrectomy cohorts showed durable reductions in BMI of 16.3 to 17.9 kg/m² at 4 to 7 years. Cardiometabolic improvements including remission of type 2 diabetes, hypertension, and dyslipidemia were demonstrated across studies, with greater weight loss associated with more sustained cardiometabolic benefit. However, psychosocial outcomes were more complex: early improvements in depression and mood scores appeared transient, with levels returning toward baseline by 5 years.
