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RCT·clinical trial, public health, internal medicine, family medicine, epidemiology·PMC10563866

Longitudinal Evaluation of an Integrated Post–COVID-19/Long COVID Management Program Consisting of Digital Interventions and Personal Support: Randomized Controlled Trial

Journal of Medical Internet Research · 8 authors, 4 centres

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AGENT 01 · STRUCTURED SUMMARY

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TL;DR

The study found that both intervention groups experienced a significantly greater reduction in symptoms compared to an untreated comparison group, but there was no significant difference in outcomes between the intervention group with a diagnostic assessment and the active control group without one.

Full summary

845 CHARS

The intervention group (IG) received a diagnostic assessment and tailored digital interventions plus personal support. The active control group (ACG) received personal support and non-tailored digital interventions. The central result was a significant reduction in symptoms over time in all groups, with a more pronounced decrease in both the IG and ACG compared to the CompG. However, there was no significant difference in symptom reduction between the IG and ACG. Limitations include the inability to disentangle the specific effects of personal support versus digital interventions, and the potential influence of placebo effects. The findings suggest that combining digital interventions and personal support can facilitate symptom recovery in PACS, but a comprehensive diagnostic assessment did not provide additional short-term benefits.

STUDY TYPE

RCT

SPECIALTY

clinical trial

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AI pipeline

FIDELITY CHECK

100% · A

ORIGINAL PAPER

PMC10563866

Longitudinal Evaluation of an Integrated Post–COVID-19/Long COVID Management Program Consisting of Digital Interventions and Personal Support: Randomized Controlled Trial

Journal of Medical Internet Research

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ABSTRACT

Abstract Background The postacute COVID-19 syndrome (PACS) can be addressed with multidisciplinary approaches, including professional support and digital interventions. Objective This research aimed to test whether patients who received a health care facilitation program including medical internet support from human personal pilots and digital interventions (intervention group [IG] and active control group [ACG]) would experience fewer symptoms and have higher work ability and social participation than an untreated comparison group (CompG). The second objective was to compare the impact of a diagnostic assessment and digital interventions tailored to patients’ personal capacity (IG) with that of only personal support and digital interventions targeting the main symptoms (ACG). Methods In total, 1020 patients with PACS were recruited. Using a randomized controlled trial design between the IG and the ACG, as well as propensity score matching to include the CompG, analyses were run with logistic regression and hierarchical-linear models. Results Symptoms decreased significantly in all groups over time (βT1-T2=0.13, t 549 =5.67, P <.001; βT2-T4=0.06, t 549 =2.83, P =.01), with a main effect of the group (β=–.15, t 549 =–2.65, P =.01) and a more pronounced effect in the IG and ACG compared to the CompG (between groups: βT1-T2=0.14, t 549 =4.31, P <.001; βT2-T4=0.14, t 549 =4.57, P <.001). Work ability and social participation were lower in the CompG, but there was no significant interaction effect. There were no group differences between the IG and the ACG. Conclusions Empowerment through personal pilots and digital interventions reduces symptoms but does not increase work ability and social participation. More longitudinal research is needed to evaluate the effects of a diagnostic assessment. Social support and digital interventions should be incorporated to facilitate health care interventions for PACS. Trial Registration ClinicalTrials.gov NCT05238415 ; https://classic.clinicaltrials.gov/ct2/show/ NCT05238415 . International Registered Report Identifier (IRRID) RR2-10.1186/s12879-022-07584-z Keywords: postacute COVID-19 syndrome, PACS, symptom reduction, work ability, social participation, personal pilots, digital interventions, empowerment, randomized controlled trial, propensity score matching, COVID-19

CITATION EXPORT

Christina Derksen, Robin Rinn, Lingling Gao et al.. Longitudinal Evaluation of an Integrated Post–COVID-19/Long COVID Management Program Consisting of Digital Interventions and Personal Support: Randomized Controlled Trial. Journal of Medical Internet Research. (2023). https://doi.org/10.2196/49342

AUTHORS

8 · 4 CENTRES

Christina Derksen, Robin Rinn, Lingling Gao, Alina Dahmen, Cay Cordes, Carina Kolb, Petra Becker, Sonia Lippke

1Health Psychology and Behavioural Medicine, Constructor University Bremen, Bremen, Germany
2Wolfson Institute of Population Health, Queen Mary University of London, London, United Kingdom
3Dr. Becker Kiliani-Klinik, Dr. Becker Klinikgruppe, Bad Windsheim, Germany
4Dr. Becker Klinikgruppe, Cologne, Germany