SEARCHCOHORTnutrition, epidemiology

cohort·nutrition, epidemiology, public health, observational study, dietetics·PMC10753393

Low-Carbohydrate Diet Macronutrient Quality and Weight Change

JAMA Network Open · 6 authors, 4 centres

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TL;DR

The LCD indices were designed to emphasize varying sources and qualities of macronutrients.

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The LCD indices were designed to emphasize varying sources and qualities of macronutrients. The central finding was a divergent association: LCDs emphasizing high-quality macronutrients from healthy plant-based foods were associated with less weight gain, whereas LCDs emphasizing animal-sourced proteins and fats or refined carbohydrates were associated with more weight gain. The study's strengths include its large sample size and long follow-up period. Limitations include potential measurement errors from self-reported data, possible residual confounding, a lack of body composition measures, and a study population limited mainly to White health professionals.

STUDY TYPE

cohort

SPECIALTY

nutrition

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100% · A

ORIGINAL PAPER

PMC10753393

Low-Carbohydrate Diet Macronutrient Quality and Weight Change

JAMA Network Open

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ABSTRACT

Key Points Question Are low-carbohydrate diets (LCDs) associated with long-term weight change, and does the source and quality of macronutrients within LCDs influence these associations? Findings In this cohort study using data from 3 large prospective cohort studies among 123 332 individuals, LCDs that emphasized high-quality proteins, fats and carbohydrates from whole grains and other healthy plant-based foods were significantly associated with slower weight gain in the long term. In contrast, LCDs emphasizing animal-sourced proteins and fats or refined carbohydrates were associated with faster weight gain. Meaning These findings underscore the importance of diet quality within LCD patterns for long-term weight management.

CITATION EXPORT

Binkai Liu, Yang Hu, Sharan K Rai et al.. Low-Carbohydrate Diet Macronutrient Quality and Weight Change. JAMA Network Open. (2023). https://doi.org/10.1001/jamanetworkopen.2023.49552

AUTHORS

6 · 4 CENTRES

Binkai Liu, Yang Hu, Sharan K Rai, Molin Wang, Frank B Hu, Qi Sun

1Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts
2Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts
3Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital, Boston, Massachusetts
4Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts