Scientific Reports · 2 authors, 2 centres
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This cross-sectional study of 10,439 US adults from NHANES 2013–2016 found that lower serum testosterone levels were significantly associated with a higher likelihood of arthritis. The association was more pronounced in women and individuals with BMI ≥ 30 kg/m².
This cross-sectional study used NHANES 2013–2016 data to examine the relationship between serum testosterone and arthritis in 10,439 US adults. Multivariate logistic regression models, smoothed curve fitting, and generalized additive models were employed. A significant negative association between serum testosterone and arthritis was found, with the arthritis group having lower testosterone levels than the non-arthritis group. Dose–response analysis showed a nonlinear and negative association. Subgroup analyses revealed the association was more significant in women and those with BMI ≥ 30 kg/m². Study limitations include reliance on self-reported arthritis diagnosis subject to recall bias, the cross-sectional design precluding causal inference, potential non-universality to other populations, and no multiple imputation for missing covariate data.
