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other·preclinical research, nutrition, micronutrients, antioxidants, nephrology·PMC10535989

Lutein Modulates Oxidative Stress, Inflammatory and Apoptotic Biomarkers Related to Di-(2-Ethylhexyl) Phthalate (DEHP) Hepato-Nephrotoxicity in Male Rats: Role of Nuclear Factor Kappa B

Toxics · 6 authors, 7 centres

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TL;DR

This preclinical animal study investigated whether lutein could mitigate hepato-nephrotoxicity induced by the environmental toxicant DEHP in male albino rats.

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This preclinical animal study investigated whether lutein could mitigate hepato-nephrotoxicity induced by the environmental toxicant DEHP in male albino rats. Co-administration of lutein (40 mg/kg) significantly attenuated these biochemical, oxidative, inflammatory, apoptotic, and histological changes. The study concludes that lutein possesses protective antioxidant, anti-inflammatory, and anti-apoptotic properties against DEHP toxicity in this rat model.

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other

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preclinical research

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ORIGINAL PAPER

PMC10535989

Lutein Modulates Oxidative Stress, Inflammatory and Apoptotic Biomarkers Related to Di-(2-Ethylhexyl) Phthalate (DEHP) Hepato-Nephrotoxicity in Male Rats: Role of Nuclear Factor Kappa B

Toxics

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ABSTRACT

Phthalates are widely distributed in our environment due to their usage in many industries, especially in plastic production, which has become an essential part of daily life. This investigation aimed to assess the potential remedial influence of lutein, a naturally occurring carotenoid, on phthalate-triggered damage to the liver and kidneys. When di-(2-ethylhexyl) phthalate (DEHP) was administered to male albino rats over sixty straight days at a dosage of 200 mg/kg body weight, it resulted in a significant increase in the serum activity of liver enzymes (AST, ALT, and GGT), alpha-fetoprotein, creatinine, and cystatin-C, as well as disruptions in the serum protein profile. In addition, intoxication with DEHP affected hepato-renal tissues’ redox balance. It increased the content of some proinflammatory cytokines, nuclear factor kappa B (Nf-κB), and apoptotic marker (caspase-3); likewise, DEHP-induced toxicity and decreased the level of anti-apoptotic protein (Bcl-2) in these tissues. Lutein administration at a dose level of 40 mg/kg b.w efficiently facilitated the changes in serum biochemical constituents, hepato-renal oxidative disturbance, and inflammatory, apoptotic, and histopathological alterations induced by DEHP intoxication. In conclusion, it can be presumed that lutein is protective as a natural carotenoid against DEHP toxicity.

CITATION EXPORT

Dina R. S. Gad El-Karim, Mohamed A. Lebda, Badriyah S. Alotaibi et al.. Lutein Modulates Oxidative Stress, Inflammatory and Apoptotic Biomarkers Related to Di-(2-Ethylhexyl) Phthalate (DEHP) Hepato-Nephrotoxicity in Male Rats: Role of Nuclear Factor Kappa B. Toxics. (2023). https://doi.org/10.3390/toxics11090742

AUTHORS

6 · 7 CENTRES

Dina R. S. Gad El-Karim, Mohamed A. Lebda, Badriyah S. Alotaibi, Attalla F. El-kott, Heba I. Ghamry, Mustafa Shukry

1Department of Pathology and Clinical Pathology, Faculty of Veterinary Medicine, Alexandria University, Alexandria 22758, Egypt
2Department of Biochemistry, Faculty of Veterinary Medicine, Alexandria University, Alexandria 22758, Egypt
3Department of Pharmaceutical Sciences, College of Pharmacy, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh 11671, Saudi Arabia
4Department of Biology, College of Science, King Khalid University, Abha 61421, Saudi Arabia
5Department of Zoology, Faculty of Science, Damanhour University, Damanhour 22511, Egypt
6Nutrition and Food Sciences, Department of Home Economics, Faculty of Home Economics, King Khalid University, P.O. Box 960, Abha 61421, Saudi Arabia
7Physiology Department, Faculty of Veterinary Medicine, Kafrelsheikh University, Kafrelsheikh 33516, Egypt

EDITOR / REVIEWER

Lei Su