Management of Locally Advanced Laryngeal Cancer—From Risk Factors to Treatment, the Experience of a Tertiary Hospital from Eastern Europe

International Journal of Environmental Research and Public Health · 12 authors, 4 centres

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TL;DR

This retrospective study analyzed 152 patients with stage III or IV laryngeal cancer diagnosed at a Romanian hospital between 2021 and 2022.

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This retrospective study analyzed 152 patients with stage III or IV laryngeal cancer diagnosed at a Romanian hospital between 2021 and 2022. The mean age was 62 years, with a male-to-female ratio of 6.6:1. The most frequent symptom was dysphonia with or without dyspnea, present in 93.42% of cases. Total laryngectomy was the most common primary treatment, performed in 63.15% of cases, while eight patients initially had organ preservation treatment. The study highlights that a large majority of patients were smokers and had poor oral hygiene.

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cohort

SPECIALTY

oncology

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ORIGINAL PAPER

PMC10048780

Management of Locally Advanced Laryngeal Cancer—From Risk Factors to Treatment, the Experience of a Tertiary Hospital from Eastern Europe

International Journal of Environmental Research and Public Health

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ABSTRACT

Laryngeal cancer is an important oncological entity in which prognosis depends on the establishment of appropriate preventive and diagnostic measures, especially in high-risk populations. We present a retrospective two-year study (January 2021 to December 2022) with 152 patients diagnosed with laryngeal cancer from a tertiary hospital in Romania. The average age of the patients was 62 years old for both sexes, with a range from 44 to 83 years. The most frequent symptom was dysphonia with or without dyspnea in 142 cases (93.42%), followed by dyspnea alone in nine patients (5.92%) and dysphagia in one case (0.66%). Surgical treatment in this study consisted of partial laryngectomy (CO 2 laser transoral tumor ablation, supraglottic horizontal laryngectomy or hemilaryngectomy), or total laryngectomy. The main treatment was total laryngectomy (63%). For the eight patients with initial organ preservation treatment, the average time of recurrence was about two-and-a-half years. For the four patients who underwent a total circular pharyngo-laryngectomy, the upper digestive tract needed to be rebuilt with a salivary bypass tube or with a tubed myocutaneous flap from the major pectoralis muscle. One strong point is characteristic of the study group in gathering patients with advanced stages of laryngeal carcinoma candidates for salvage surgery and extended reconstruction methods. The development of new prevention protocols is mandatory in Eastern European countries.

CITATION EXPORT

Anca-Ionela Cîrstea, Șerban Vifor Gabriel Berteșteanu, Răzvan-Valentin Scăunașu et al.. Management of Locally Advanced Laryngeal Cancer—From Risk Factors to Treatment, the Experience of a Tertiary Hospital from Eastern Europe. International Journal of Environmental Research and Public Health. (2023). https://doi.org/10.3390/ijerph20064737

AUTHORS

12 · 4 CENTRES

Anca-Ionela Cîrstea, Șerban Vifor Gabriel Berteșteanu, Răzvan-Valentin Scăunașu, Bogdan Popescu, Paula Luiza Bejenaru, Catrinel Beatrice Simion-Antonie, Gloria Simona Berteșteanu, Teodora Elena Diaconu, Petra Bianca Taher, Simona-Andreea Rujan, Irina-Doinița Oașă, Raluca Grigore

1Department 12-Otorhynolaryngology, Ophtalmology, Faculty of Medicine, “Carol Davila” University of Medicine and Pharmacy, 050474 Bucharest, Romania; [email protected] (A.-I.C.);
2Department of ENT, Head and Neck Surgery, Colţea Clinical Hospital, 030167 Bucharest, Romania
3Department of General Surgery, Colţea Clinical Hospital, 030167 Bucharest, Romania
4Department of ENT, Head and Neck Surgery, “Carol Davila” Emergency Central Military Hospital, 010825 Bucharest, Romania

EDITOR / REVIEWER

Paul B. Tchounwou, Monica Rienzo, Erika Zazzo, Małgorzata Pawlikowska, Felice Crocetto, Octavian Sabin Tataru