SEARCHSYSTEMATIC_REVIEWpediatrics, systematic review

systematic_review·pediatrics, systematic review, epidemiology, neurology, oncology·PMC10464630

Mapping Two Decades of Paediatric Down Syndrome Research Literature.

The Ulster Medical Journal · 6 authors, 8 centres

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TL;DR

Researchers analyzed publications by country, methodology, and health themes.

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Researchers analyzed publications by country, methodology, and health themes. The majority of publications (33.3%) used a cross-sectional design, while interventional (5.6%), qualitative (2.7%), and mixed-method studies (1.6%) were rare. Primary research themes were dominated by development & cognition (13.1%), neurology (9.9%), and oncology (9.8%), with notably fewer studies on genitourinary health (0.9%), growth (0.9%), mortality (0.9%), and child protection (0.2%). The findings highlight research gaps and suggest a need to rebalance focus towards improving the health of live-born children with DS.

STUDY TYPE

systematic_review

SPECIALTY

pediatrics

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100% · A

ORIGINAL PAPER

PMC10464630

Mapping Two Decades of Paediatric Down Syndrome Research Literature.

The Ulster Medical Journal

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ABSTRACT

Abstract Background While research has led to significant advancements in the health and life expectancy of children with Down Syndrome (DS), there remains a significant burden of disease and health inequity. Further research, focused on areas of greatest need, is imperative to address this. An understanding of what research has been undertaken, and any existing gaps, helps to guide future academic efforts. Methods We utilised an epistemological approach to summarise two decades of paediatric DS literature. Publications were categorised according to the country of origin, methodology, primary health themes and subcategory research themes. Results Across 5,800 paediatric DS publications we demonstrate a general increase in the number of publications in this field between 2000 and 2014, with a trending decline thereafter. The majority of publications were affiliated with Institutions based in Western countries. The majority of studies utilised a cross-sectional methodology (33.3%), while relatively few were interventional (5.6%), qualitative (2.7%) or mixed-method studies (1.6%). Most publications focused on development & cognition (13.1%), neurology (9.9%) and oncology (9.8%), with fewer focusing on genitourinary health (0.9%), growth (0.9%), mortality (0.9%) and child protection (0.2%). Conclusion These findings highlight areas of relative paucity within the paediatric DS literature which may warrant increased academic attention.

CITATION EXPORT

Caoimhe McKenna, Anne Schilder, Rachel Xue Ning Lee et al.. Mapping Two Decades of Paediatric Down Syndrome Research Literature.. The Ulster Medical Journal. (2023)

AUTHORS

6 · 8 CENTRES

Caoimhe McKenna, Anne Schilder, Rachel Xue Ning Lee, Logan Manikam, Roderick Venekamp, Monica Lakhanpaul

1UCL Great Ormond Street Institute of Child Health
2evidENT, UCL Ear Institute and NIHR UCLH Biomedical Research Centre 3. UCL Institute of Health Informatics
3UMC Utrecht
4Queen’s University Belfast
5NI Regional Molecular Diagnostics Service, Belfast Health and Social Care Trust
6Queen’s Medical Centre, Nottingham University Hospitals NHS Trust
7Whittington Health NHS Trust Dr Caoimhe McKenna Department of Clinical Genetics NI Regional Molecular Diagnostics Service Belfast, BT9 7AB
8Department of Clinical Genetics NI Regional Molecular Diagnostics Service Belfast, BT9 7AB