SEARCHNARRATIVE_REVIEWcardiology, preclinical research

narrative_review·cardiology, preclinical research, biomedical research, antioxidants·PMC10052127

Marine-Derived Compounds Applied in Cardiovascular Diseases: Submerged Medicinal Industry

Marine Drugs · 6 authors, 5 centres

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TL;DR

The paper is a narrative review discussing the potential of marine-derived compounds as therapeutic agents for cardiovascular diseases.

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The paper is a narrative review discussing the potential of marine-derived compounds as therapeutic agents for cardiovascular diseases. It surveys literature on the pharmacological activities of various bioactive metabolites from marine organisms, highlighting their antioxidant and anti-inflammatory properties. The review notes the limitations of current synthetic drugs and positions marine sources as a rich reservoir for future drug discovery.

STUDY TYPE

narrative_review

SPECIALTY

cardiology

SUMMARISED BY

AI pipeline

FIDELITY CHECK

100% · A

ORIGINAL PAPER

PMC10052127

Marine-Derived Compounds Applied in Cardiovascular Diseases: Submerged Medicinal Industry

Marine Drugs

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ABSTRACT

Cardiovascular diseases (CVDs) are among the most impactful illnesses globally. Currently, the available therapeutic option has several side effects, including hypotension, bradycardia, arrhythmia, and alteration in different ion concentrations. Recently, bioactive compounds from natural sources, including plants, microorganisms, and marine creatures, have gained a lot of interest. Marine sources serve as reservoirs for new bioactive metabolites with various pharmacological activities. The marine-derived compound such as omega-3 acid ethyl esters, xyloketal B, asperlin, and saringosterol showed promising results in several CVDs. The present review focuses on marine-derived compounds’ cardioprotective potential for hypertension, ischemic heart disease, myocardial infarction, and atherosclerosis. In addition to therapeutic alternatives, the current use of marine-derived components, the future trajectory, and restrictions are also reviewed.

CITATION EXPORT

Wasim Akram, Mohd Rihan, Sakeel Ahmed et al.. Marine-Derived Compounds Applied in Cardiovascular Diseases: Submerged Medicinal Industry. Marine Drugs. (2023). https://doi.org/10.3390/md21030193

AUTHORS

6 · 5 CENTRES

Wasim Akram, Mohd Rihan, Sakeel Ahmed, Swamita Arora, Sameer Ahmad, Rahul Vashishth

1Department of Pharmacology, SPER, Jamia Hamdard, New Delhi 110062, India
2Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, Mohali 160062, India
3Department of Pharmacology, R. V. Northland Institute of Pharmacy, Dadri 203207, India
4Department of Food Technology Jamia Hamdard, New Delhi 110062, India
5School of BioSciences and Technology-Food Technology, Vellore Institute of Technology, Vellore 632014, India

EDITOR / REVIEWER

Alexandros Tsoupras