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TL;DR
Female Wistar rats fed a high-fat diet (29% fat) before and during pregnancy and lactation produced breast milk with reduced endocannabinoid levels (AEA and 2-AG), contrary to the authors' hypothesis.
Frontiers in Endocrinology · 11 authors, 3 centres
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Female Wistar rats fed a high-fat diet (29% fat) before and during pregnancy and lactation produced breast milk with reduced endocannabinoid levels (AEA and 2-AG), contrary to the authors' hypothesis.
Female Wistar rats were fed a control (10% fat) or high-fat (29% fat) isocaloric diet (~3.9 kcal/g) for 8 weeks before mating and throughout gestation and lactation. Milk endocannabinoids and fatty acids were quantified by mass spectrometry across lactation. Cannabinoid and dopamine signaling were evaluated in the nucleus accumbens of weanling offspring, and food preference was assessed in adolescence. Contrary to the hypothesis, maternal HF diet significantly decreased both AEA and 2-AG in breast milk, alongside reduced n3 and n6 PUFA at mid-lactation. No changes were found in mammary gland endocannabinoid-synthesizing or degrading enzyme content.