Food & Nutrition Research · 5 authors, 4 centres
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This mouse study found that a maternal cafeteria diet led to reduced social interaction in male offspring, but supplementation with methyl donors normalized social behavior. However, the methyl donor supplementation also increased anxiety-like behaviors.
This preclinical study used C57BL/6 female mice randomized to four dietary formulas (control chow, cafeteria, control+methyl donor, cafeteria+methyl donor) during pre-gestational, gestational, and lactation periods. Male offspring at 2 months were behaviorally phenotyped using the Three-Chamber Test, Open Field Test, and Marble Burying Test. The study found that offspring from CAF-fed dams had a lower social interaction index compared to CT group offspring. Maternal methyl donor supplementation to the CAF diet (CAF+M) normalized this social interaction. However, the CAF diet also promoted anxiety-like behavior, and CAF+M supplementation increased specific anxiety-like behaviors (rearing and wall leaning).
