“
TL;DR
Muc2 mRNA was substantially downregulated in PE-MP groups, with a dose-dependent effect, and goblet cell measurements and mucin area % confirmed reduced mucus secretion.
International Journal of Molecular Sciences · 17 authors, 12 centres
This summary was generated by AI from a single paper. It has not been reviewed by a clinician and is not clinical advice. Verify against the source before acting on it.
Muc2 mRNA was substantially downregulated in PE-MP groups, with a dose-dependent effect, and goblet cell measurements and mucin area % confirmed reduced mucus secretion.
Muc2 mRNA was substantially downregulated in PE-MP groups, with a dose-dependent effect, and goblet cell measurements and mucin area % confirmed reduced mucus secretion. PE-MP significantly upregulated MLCK, downregulated occludin and ZO-1 mRNA, and decreased claudin-1 immunoreactivity. Low-dose PE-MP did not change TNF-α, while high-dose significantly decreased it; both doses elevated IL-1β. Melatonin significantly restored mucin depletion, upregulated occludin and ZO-1 mRNA, enhanced claudin-1 protein expression, downregulated MLCK, decreased IL-1β, and restored TNF-α toward controls. Discrepancies with some prior studies using polystyrene or polypropylene MP were noted, likely attributable to differences in MP type, particle size, route, and duration of administration.