SEARCHRCTpediatrics, surgery

RCT·pediatrics, surgery, pediatric ophthalmology, antioxidants, clinical trial·PMC10044879

Melatonin in Newborn Infants Undergoing Surgery: A Pilot Study on Its Effects on Postoperative Oxidative Stress

Antioxidants · 11 authors, 6 centres

AI SUMMARY

FIDELITY 100%

POPULATIONNewborn infants >34 weeks gestational age requiring surgery

INTERVENTIONSingle dose of oral melatonin 0.5 mg/kg preoperatively

COMPARISONUntreated control group

This summary was generated by AI from a single paper. It has not been reviewed by a clinician and is not clinical advice. Verify against the source before acting on it.

AGENT 01 · STRUCTURED SUMMARY

TRACE TO SOURCE

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TL;DR

This randomized, evaluator-blinded pilot trial found that a single preoperative dose of oral melatonin in newborn infants undergoing surgery significantly reduced postoperative levels of oxidative stress biomarkers compared to an untreated control group.

Full summary

789 CHARS

This evaluator-blinded, randomized pilot study enrolled 23 newborn infants requiring surgery. Ten infants received a single preoperative dose of oral melatonin (0.5 mg/kg), and 13 served as untreated controls. Plasma melatonin and oxidative stress biomarkers (NPBI, F2-IsoPs, AOPP) were measured before and after surgery. In the melatonin group, mean postoperative levels of NPBI, F2-IsoPs, and AOPP significantly decreased from preoperative values. Endogenous melatonin also increased physiologically from the pre- to postoperative period in the untreated group, but this rise did not significantly reduce oxidative stress markers. The findings suggest a potential protective role for melatonin against surgical oxidative stress, but larger trials are needed to confirm clinical benefits.

PICO

PPOPULATION

Newborn infants >34 weeks gestational age requiring surgery

IINTERVENTION

Single dose of oral melatonin 0.5 mg/kg preoperatively

OOUTCOME

Plasma concentrations of oxidative stress biomarkers (NPBI, AOPP, F2-IsoPs)

STUDY TYPE

RCT

SPECIALTY

pediatrics

SUMMARISED BY

AI pipeline

FIDELITY CHECK

100% · A

ORIGINAL PAPER

PMC10044879

Melatonin in Newborn Infants Undergoing Surgery: A Pilot Study on Its Effects on Postoperative Oxidative Stress

Antioxidants

READ THE FULL PAPER

ABSTRACT

Surgery is frequently associated with excessive oxidative stress. Melatonin acts as an antioxidant and transient melatonin deficiency has been described in neonatal surgical patients. This randomized, blinded, prospective pilot study tested the hypothesis that oral melatonin supplementation in newborn infants undergoing surgery is effective in reducing perioperative oxidative stress. A total of twenty-three newborn infants requiring surgery were enrolled: 10 received a single dose of oral melatonin 0.5 mg/kg in the morning, before surgery (MEL group), and 13 newborns served as the control group (untreated group). Plasma concentrations of melatonin, Non-Protein-Bound Iron (NPBI), Advanced Oxidation Protein Products (AOPP), and F2-Isoprostanes (F2-IsoPs) were measured. Both in the pre- and postoperative period, melatonin concentrations were significantly higher in the MEL group than in the untreated group (preoperative: 1265.50 ± 717.03 vs. 23.23 ± 17.71 pg/mL, p < 0.0001; postoperative: 1465.20 ± 538.38 vs. 56.47 ± 37.18 pg/mL, p < 0.0001). Melatonin significantly increased from the pre- to postoperative period in the untreated group (23.23 ± 17.71 vs. 56.47 ± 37.18 pg/mL; pg/mL p = 0.006). In the MEL group, the mean blood concentrations of NPBI, F2-IsoPs, and AOPP significantly decreased from the pre- to the postoperative period (4.69 ± 3.85 vs. 1.65 ± 1.18 micromol/dL, p = 0.049; 128.40 ± 92.30 vs. 50.25 ± 47.47 pg/mL, p = 0.037 and 65.18 ± 15.50 vs. 43.98 ± 17.92 micromol/dL, p = 0.022, respectively). Melatonin concentration increases physiologically from the pre- to the postoperative period, suggesting a defensive physiologic response to counteract oxidative stress. The administration of exogenous melatonin in newborn infants undergoing surgery reduces lipid and protein peroxidation in the postoperative period, showing a potential role in protecting babies from the deleterious consequences of oxidative stress.

CITATION EXPORT

Serafina Perrone, Carmelo Romeo, Lucia Marseglia et al.. Melatonin in Newborn Infants Undergoing Surgery: A Pilot Study on Its Effects on Postoperative Oxidative Stress. Antioxidants. (2023). https://doi.org/10.3390/antiox12030563

AUTHORS

11 · 6 CENTRES

Serafina Perrone, Carmelo Romeo, Lucia Marseglia, Sara Manti, Cristina Rizzo, Silvia Carloni, Maria Cristina Albertini, Walter Balduini, Giuseppe Buonocore, Michael D. Weiss, Eloisa Gitto

1Department of Medicine and Surgery, Neonatology Unit, Pietro Barilla Children’s Hospital, University of Parma, 43121 Parma, Italy
2Department of Human Pathology of the Adult and Developmental Age, Pediatric Surgery Unit, University of Messina, 98124 Messina, Italy
3Department of Human Pathology of the Adult and Developmental Age, Neonatal Intensive Care Unit, University of Messina, 98125 Messina, Italy
4Department of Biomolecular Sciences, University of Urbino Carlo Bo, 61029 Urbino, Italy
5Department of Molecular and Developmental Medicine, University of Siena, 53100 Siena, Italy
6Department of Pediatrics, University of Florida, Gainesville, FL 32610, USA

EDITOR / REVIEWER

Stanley Omaye