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TL;DR
In a preclinical study, Mentha rotundifolia aqueous extract was analyzed for antioxidant and neuroprotective effects against H2O2-induced oxidative stress in animals.
Frontiers in Neuroscience · 5 authors, 3 centres
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In a preclinical study, Mentha rotundifolia aqueous extract was analyzed for antioxidant and neuroprotective effects against H2O2-induced oxidative stress in animals.
The aqueous extract of Mentha rotundifolia leaves was characterized by LC-MS/MS, revealing kaempferol glucuronide as the dominant compound at 85%. In vitro antioxidant activity was assessed via DPPH and ABTS assays, yielding IC50 values of 26.47 and 41.21 μg/mL respectively. In vivo, H2O2 was administered to induce oxidative stress and neurotoxicity, and animals were pre-treated with the extract. Behavioral assessments included Open Field, Y-maze, Rotarod, and tail immersion tests. H2O2 exposure significantly decreased locomotion activity, induced anxiety-like behavior, and impaired spatial working and reference memory. Pre-treatment with the extract, particularly at 125 mg/kg, attenuated these behavioral changes. The extract also dose-dependently increased tail withdrawal latency and improved hepatic biomarkers, with AST and ALT levels at 250 mg/kg comparable to tap water controls. However, the 250 mg/kg dose showed reduced locomotor activity, which remained unexplained.