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TL;DR
This meta-analysis reexamined five public 16S rRNA datasets and found that osteoporosis is associated with an increased abundance of opportunistic pathogens and a depletion of short-chain fatty acid-producing bacteria in the gut.
Microbiology Spectrum · 2 authors, 2 centres
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This meta-analysis reexamined five public 16S rRNA datasets and found that osteoporosis is associated with an increased abundance of opportunistic pathogens and a depletion of short-chain fatty acid-producing bacteria in the gut.
The study conducted a meta-analysis of five publicly available 16S rRNA datasets to identify gut microbial signatures associated with osteoporosis. After correcting for batch effects, the analysis found significant compositional shifts in the osteoporosis group, including increased relative abundance of opportunistic pathogens like *Clostridium sensu stricto*, *Bacteroides*, and *Intestinibacter*, and decreased relative abundance of short-chain fatty acid (SCFA) producers such as *Collinsella*, *Megasphaera*, and *Agathobaculum*. Functional prediction showed a depletion of SCFA biosynthesis and amino acid biosynthesis pathways in the osteoporosis group. The findings suggest microbial dysbiosis may be linked to osteoporosis pathogenesis, but causal evidence is not provided.