Metabolic adaptations of cancer in extreme tumor microenvironments

Cancer Science · 4 authors, 2 centres

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FIDELITY 100%

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TL;DR

The authors conclude that understanding these adaptations at single-cell and organelle levels may identify new therapeutic targets.

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The authors conclude that understanding these adaptations at single-cell and organelle levels may identify new therapeutic targets.

STUDY TYPE

narrative_review

SPECIALTY

oncology

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AI pipeline

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100% · A

ORIGINAL PAPER

PMC10067430

Metabolic adaptations of cancer in extreme tumor microenvironments

Cancer Science

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ABSTRACT

Abstract Cancer cells are highly heterogeneous to adapt to extreme tumor microenvironments (TMEs). TMEs challenge cancer cells via hypoxia, nutrition starvation, and acidic pH, promoting invasion and metastasis concomitant with genetic, epigenetic, and metabolic alterations. Metabolic adaptation to an extreme TME could allow cancer cells to evade cell death and immune responses, as well as resulting in drug resistance, recurrence, and poor patient prognosis. Therefore, elucidation of the metabolic adaptation of malignant cancer cells within TMEs is necessary, however, most are still elusive. Recently, adaptation of cancer cells within the TME can be analyzed via cell–cell interactions at the single‐cell level. In addition, information into organelle–organelle interactions has recently been obtained. These cell–cell, and organelle–organelle interactions demonstrate the potential as new cancer therapy targets, as they play essential roles in the metabolic adaptation of cancer cells to the TME. In this manuscript, we review (1) metabolic adaptations within tumor microenvironments through (2) cell‐to‐cell, and (3) organelle–organelle metabolic interactions. Keywords: acidic pH, cancer metabolism, hypoxia, nutrient starvation, organelle

CITATION EXPORT

Ryuichi Nakahara, Keisuke Maeda, Sho Aki et al.. Metabolic adaptations of cancer in extreme tumor microenvironments. Cancer Science. (2023). https://doi.org/10.1111/cas.15722

AUTHORS

4 · 2 CENTRES

Ryuichi Nakahara, Keisuke Maeda, Sho Aki, Tsuyoshi Osawa

1 Division of Nutriomics and Oncology, RCAST, The University of Tokyo, Tokyo, Japan
2 Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo, Tokyo, Japan