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TL;DR
It concludes that metabolomic profiling of tears and corneal tissue holds potential for identifying biomarkers and understanding disease mechanisms, though standardization and larger studies are needed.
Metabolites · 4 authors, 7 centres
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It concludes that metabolomic profiling of tears and corneal tissue holds potential for identifying biomarkers and understanding disease mechanisms, though standardization and larger studies are needed.
This narrative review synthesizes literature on metabolomics applications in human corneal diseases, including dry eye disease, keratoconus, Sjogren’s syndrome, refractive surgery, and diabetic corneas. Central findings from cited studies indicate significant metabolomic alterations are associated with these conditions, linking changes to processes like oxidation and inflammation. The review notes that while this research offers valuable insights, challenges remain, including the influence of varying disease severity and a need for standardized techniques and larger sample sizes with longer follow-up.