Toxins · 5 authors, 3 centres
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This study used metagenomic sequencing in a mouse model to show that exposure to the mycotoxin deoxynivalenol significantly alters gut microbiota composition, with changes mostly recovering spontaneously after 2 weeks, but prebiotic inulin supplementation had mixed effects depending on the exposure dose.
The study investigated the impact of deoxynivalenol (DON) exposure (2 mg/kg bw/day or 5 mg/kg bw/day for 2 weeks) on the gut microbiota of mice using whole-genome sequencing. DON exposure increased the relative abundance of species like Akkermansia muciniphila and decreased others like Oscillibacter sp. 1-3. After a 2-week recovery period, most microbial alterations from low-dose exposure recovered spontaneously, while high-dose exposure changes did not fully recover. Administering the prebiotic inulin during recovery promoted microbiome and functional gene recovery after low-dose DON exposure but exacerbated changes and decreased diversity after high-dose exposure. The findings highlight the dose-dependent effects of DON on the gut microbiome and the complexities of prebiotic-based recovery strategies.
