Life · 1 author, 2 centres
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This narrative review examines how autophagy, a cellular degradation process, is linked to multiple steps of metastasis in neuroblastoma, a paediatric cancer. It discusses various molecular players and compounds that modulate autophagy and may influence metastatic progression.
This is a narrative review analyzing preclinical literature on the mechanistic link between autophagy and metastasis in neuroblastoma (NB). It describes autophagy's context-dependent role, which may suppress early metastatic steps like invasion and migration but facilitate later stages such as anoikis resistance and metastatic outbreak. The review maps the function of various molecular players and compounds, including the autophagy inhibitors 3-MA and hydroxychloroquine (HCQ), to different steps of the metastatic cascade. A key conclusion is that the effect of these modulators on metastasis is context-dependent, suggesting they could serve as potential biomarkers or therapeutic targets.
