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TL;DR
The authors describe biofilms as structured communities of microorganisms protected by an extracellular polymeric substance (EPS) matrix, which shields them from host defenses and antibiotics.
Microorganisms · 6 authors, 5 centres
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The authors describe biofilms as structured communities of microorganisms protected by an extracellular polymeric substance (EPS) matrix, which shields them from host defenses and antibiotics.
The authors describe biofilms as structured communities of microorganisms protected by an extracellular polymeric substance (EPS) matrix, which shields them from host defenses and antibiotics. The review discusses multiple control strategies, including surface engineering to prevent adhesion, the use of antibiotics and antimicrobial coatings, and novel approaches like phage therapy, quorum-sensing inhibitors, and CRISPR-Cas gene editing. A central implication is that established biofilms are difficult to eradicate, necessitating a multi-faceted approach combining physical, biological, and chemical methods.