Neurology International · 8 authors, 2 centres
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This observational pilot study analyzed mitochondrial and microbiota markers in a Peruvian cohort of fibromyalgia patients. It found sex-dependent differences in the abundance of the bacterial genera Ruminococcus and Pseudomonas, but no significant differences in mitochondrial mass or total antioxidant capacity.
This observational pilot study analyzed mitochondrial and microbiota molecular markers in a cohort of female and male fibromyalgia (FM) patients. The central results showed that while there were no significant differences between sexes in mitochondrial mass or TAC, the study found a sex-dependent imbalance. Additionally, the Firmicutes/Bacteroidetes ratio was below a previously reported healthy range. The authors suggest these findings provide a starting point for understanding microbiota differences in FM but note that drug use, particularly NSAIDs, could be a confounding factor. The study concludes that the microbiota–mitochondria axis, including sIgA, Ruminococcus spp., and Pseudomonas spp., may be a promising area for future research into FM diagnostics and patient classification.
