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TL;DR
The review notes that while protein substitutes for PKU often contain age-appropriate vitamins, they may not account for reduced nutrient interactions from excluded food groups, leading to persistent low serum levels of some micronutrients.
International Journal of Molecular Sciences · 8 authors, 4 centres
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The review notes that while protein substitutes for PKU often contain age-appropriate vitamins, they may not account for reduced nutrient interactions from excluded food groups, leading to persistent low serum levels of some micronutrients.
The review notes that while protein substitutes for PKU often contain age-appropriate vitamins, they may not account for reduced nutrient interactions from excluded food groups, leading to persistent low serum levels of some micronutrients. It mentions that over 70% of PKU patients would have inadequate intakes of 11 micronutrients without supplementation. Limitations include a reliance on case studies and heterogeneous clinical practices. The implications are that standardized, tailored micronutrient formulations and further high-quality research are needed to optimize supplementation and improve patient outcomes.