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TL;DR
In 52 children aged 6 to <36 months living with HIV, those with severe acute malnutrition had similar zinc and selenium levels to those without SAM after nutritional rehabilitation and ART initiation, and albumin normalized by week 48.
BMC Nutrition · 15 authors, 12 centres
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In 52 children aged 6 to <36 months living with HIV, those with severe acute malnutrition had similar zinc and selenium levels to those without SAM after nutritional rehabilitation and ART initiation, and albumin normalized by week 48.
This secondary analysis of the IMPAACT P1092 Phase IV multicenter open-label non-randomized study enrolled 52 children aged 6 to <36 months living with HIV across sites in Malawi, Tanzania, Uganda, and Zimbabwe. Twenty-five children with SAM were enrolled after 10–18 days of nutritional rehabilitation, and 27 with mild malnutrition or normal nutrition served as comparators. Zinc, selenium, total protein, and albumin were measured at entry and over 48 weeks. Zinc deficiency was present in only 2 of 25 SAM participants at entry, and mean zinc and selenium levels were similar between cohorts at baseline and over 48 weeks. Serum albumin was significantly lower in the SAM cohort at entry but normalized to non-SAM levels by week 48. Total protein was similar between cohorts throughout. The study was limited by its small sample size, the 10–18 day nutritional rehabilitation period before baseline sampling, exclusion of children with moderate malnutrition, and inability to assess complete dietary intake.