“
TL;DR
This narrative review by Shen synthesizes published literature on vitamin D metabolism in CKD, the definition and risk factors for vitamin D deficiency in this population, and the types of vitamin D available for supplementation.
Medicine · 1 author, 1 centre
This summary was generated by AI from a single paper. It has not been reviewed by a clinician and is not clinical advice. Verify against the source before acting on it.
This narrative review by Shen synthesizes published literature on vitamin D metabolism in CKD, the definition and risk factors for vitamin D deficiency in this population, and the types of vitamin D available for supplementation.
This narrative review by Shen synthesizes published literature on vitamin D metabolism in CKD, the definition and risk factors for vitamin D deficiency in this population, and the types of vitamin D available for supplementation. The author describes how declining renal 1α-hydroxylase activity in CKD reduces 1,25(OH)₂D synthesis, contributing to hypocalcemia and secondary hyperparathyroidism. A historical shift in clinical practice is documented: aggressive use of bioactive vitamin D analogs led to increased hypercalcemia, hyperphosphatemia, and vascular calcification, prompting renewed focus on nutritional vitamin D as a safer alternative.