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TL;DR
Zinc stored in presynaptic vesicles via the ZnT3 transporter is released into synapses alongside glutamate, where it competes for binding at postsynaptic NMDA and AMPA receptors.
Febs Letters · 2 authors, 2 centres
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Zinc stored in presynaptic vesicles via the ZnT3 transporter is released into synapses alongside glutamate, where it competes for binding at postsynaptic NMDA and AMPA receptors.
Zinc stored in presynaptic vesicles via the ZnT3 transporter is released into synapses alongside glutamate, where it competes for binding at postsynaptic NMDA and AMPA receptors. Electrophysiology experiments using the fast chelator ZX1, which chelates zinc approximately 200 times more rapidly than calcium-EDTA, demonstrated that synaptic zinc attenuates excitatory postsynaptic currents in the dorsal cochlear nucleus. Noise-exposed mice showed reduced vesicular zinc and diminished EPSC response to ZX1, suggesting zinc depletion following sustained loud sound exposure. In the olfactory bulb, mobile zinc is released from glomerular synapses upon electrical stimulation and modulates AMPA receptor responses in a cell-type-specific manner.