Plant Foods for Human Nutrition (Dordrecht, Netherlands) · 4 authors, 2 centres
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Bioassay-guided fractionation was used to isolate major constituents of the fruit, which were then tested in vitro against key enzymes implicated in metabolic syndrome: α-glucosidase and α-amylase for carbohydrate metabolism, pancreatic lipase for lipid metabolism, ACE and renin for hypertension, xanthine oxidase for oxidative stress, and inducible nitric oxide synthase for inflammation.
Bioassay-guided fractionation was used to isolate major constituents of the fruit, which were then tested in vitro against key enzymes implicated in metabolic syndrome: α-glucosidase and α-amylase for carbohydrate metabolism, pancreatic lipase for lipid metabolism, ACE and renin for hypertension, xanthine oxidase for oxidative stress, and inducible nitric oxide synthase for inflammation. The report states that these tests revealed potent inhibitory potential against targets related to diabetes, obesity, and hypertension. In silico docking was used to determine binding modes of the isolated compounds with α-glucosidase, ACE, and iNOS. As an in vitro and computational investigation, the work lacks in vivo validation, and the authors explicitly identify in vivo testing as a future direction for functional food evaluation.
