SEARCHCOHORToncology, clinical nutrition

cohort·oncology, clinical nutrition, nutrition, epidemiology, public health·PMC10445343

Multicentric, observational, longitudinal study for the evaluation of nutritional management implications in newly diagnosed Italian cancer patients: the Italian Registry of Malnutrition in Oncology (IRMO)

BMJ Open · 14 authors, 5 centres

AI SUMMARY

FIDELITY 100%

POPULATIONNewly diagnosed Italian cancer patients or those with metastatic disease, candidates for active treatment.

INTERVENTIONObservational collection of clinical and nutritional data, including the use of nutritional support.

COMPARISONComparison will be made between patients at high risk of malnutrition (NRS 2002 score >=3) and low-risk patients.

This summary was generated by AI from a single paper. It has not been reviewed by a clinician and is not clinical advice. Verify against the source before acting on it.

AGENT 01 · STRUCTURED SUMMARY

TRACE TO SOURCE

“

TL;DR

This is a protocol for an observational registry designed to collect real-world data on newly diagnosed Italian cancer patients to evaluate how malnutrition and nutritional support affect survival, treatment toxicity, and quality of life.

Full summary

439 CHARS

This paper outlines the protocol for the Italian Registry of Malnutrition in Oncology (IRMO), a multicentre, observational, longitudinal registry. The registry is described as innovative for being the first Italian real-world register for this purpose, with the goal of improving nutritional care practices and generating evidence for cost-effectiveness. The study is in the protocol phase; no patient results or outcome data are reported.

PICO

PPOPULATION

Newly diagnosed Italian cancer patients or those with metastatic disease, candidates for active treatment.

IINTERVENTION

Observational collection of clinical and nutritional data, including the use of nutritional support.

OOUTCOME

Overall survival, progression-free survival, symptoms, and quality of life.

STUDY TYPE

cohort

SPECIALTY

oncology

SUMMARISED BY

AI pipeline

FIDELITY CHECK

100% · A

ORIGINAL PAPER

PMC10445343

Multicentric, observational, longitudinal study for the evaluation of nutritional management implications in newly diagnosed Italian cancer patients: the Italian Registry of Malnutrition in Oncology (IRMO)

BMJ Open

READ THE FULL PAPER

ABSTRACT

Abstract Background Malnutrition is a frequent problem in oncology and is associated with reduced response to cancer treatments, increased drug-related toxicity, higher rates of clinical complications, reduced quality of life (QoL) and worse prognosis. Guidelines on clinical nutrition in oncology emphasise the usefulness of early assessment of nutritional status for a prompt identification of malnutrition and the implementation of effective interventions, but no real-world clinical data are available on the adequate management of nutritional support in patients with cancer in Italy. Methods and analysis This is an observational, longitudinal, multicentre registry of patients with a new diagnosis of cancer or metastatic disease, candidates for active treatment. They will be identified in at least 15 Italian oncological centres, members of the Alliance Against Cancer Working Group ‘Survivorship Care and Nutritional Support’. At least 1500 patients with cancer are expected to be enrolled each year. Detailed clinical and nutritional data will be collected by oncologists and clinical nutritionists during the visits foreseen in the clinical practice, through an ad hoc developed digital platform (e-Nutracare). The effects of malnutrition and nutritional support—at diagnosis and during follow-up—on overall survival and progression-free survival, as well as on patients’ symptoms and QoL, will be investigated. Ethics and dissemination The study protocol was approved by the Ethics Committee of the Fondazione IRCCS Policlinico San Matteo, Pavia, Italy and from the Ethics Committees of all other participating centres. An informed consent will be obtained from each patient enrolled in the study. Study findings will be disseminated through peer-reviewed journals, conferences and patients with cancer or professional associations. The registry will allow a better monitoring of the nutritional status of patients with cancer, promoting adequate and sustainable nutritional support, with the ultimate goal of improving the care and prognosis of these patients. Keywords: quality of life, nutritional support, registries

CITATION EXPORT

Cristina Bosetti, Amanda Casirati, Valentina Da Prat et al.. Multicentric, observational, longitudinal study for the evaluation of nutritional management implications in newly diagnosed Italian cancer patients: the Italian Registry of Malnutrition in Oncology (IRMO). BMJ Open. (2023). https://doi.org/10.1136/bmjopen-2023-071858

AUTHORS

14 · 5 CENTRES

Cristina Bosetti, Amanda Casirati, Valentina Da Prat, Sara Masi, Silvia Crotti, Alessandra Ferrari, Lorenzo Perrone, Francesco Serra, Claudia Santucci, Emanuele Cereda, Elisabetta Iannelli, Francesco De Lorenzo, Paolo Pedrazzoli, Riccardo Caccialanza

1 Department of Oncology, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy
2 Clinical Nutrition and Dietetics Unit, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy
3 Medical Oncology Unit, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy
4 Italian Federation of Volunteer-based Cancer Organizations, Rome, Italy
5 Department of Internal Medicine, University of Pavia, Pavia, Italy