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TL;DR
The method successfully detected spectral and textural differences between normal tissues and those from embryos with maternal folic acid deficiency.
Journal of Digital Imaging · 4 authors, 2 centres
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The method successfully detected spectral and textural differences between normal tissues and those from embryos with maternal folic acid deficiency.
The third endmember indicated changes in retinal and lens texture. These findings were consistent with observed microstructural and autofluorescence alterations. The study demonstrates the method's ability to discriminate pathological tissues based on optical properties without staining. Limitations include the preclinical, animal-based model and the need for further validation studies before clinical application.