SEARCHNARRATIVE_REVIEWoncology, immunology

narrative_review·oncology, immunology, hematology, epidemiology, preclinical research·PMC10052198

Mycoviruses in Fungi: Carcinogenesis of Fungal Agents May Not Always Be Mycotoxin Related

Journal of Fungi · 1 author, 1 centre

AI SUMMARY

FIDELITY 100%

This summary was generated by AI from a single paper. It has not been reviewed by a clinician and is not clinical advice. Verify against the source before acting on it.

AGENT 01 · STRUCTURED SUMMARY

TRACE TO SOURCE

“

TL;DR

The authors cite epidemiological associations, such as higher cancer rates in occupations with high fungal exposure and an inverse relationship between atopic conditions and certain cancers.

Full summary

190 CHARS

The authors cite epidemiological associations, such as higher cancer rates in occupations with high fungal exposure and an inverse relationship between atopic conditions and certain cancers.

STUDY TYPE

narrative_review

SPECIALTY

oncology

SUMMARISED BY

AI pipeline

FIDELITY CHECK

100% · A

ORIGINAL PAPER

PMC10052198

Mycoviruses in Fungi: Carcinogenesis of Fungal Agents May Not Always Be Mycotoxin Related

Journal of Fungi

READ THE FULL PAPER

ABSTRACT

Abstract Certain viruses have been found to induce diverse biological pathways to carcinogenesis, evidenced by the presence of viral gene products in some tumors. Despite the fact that many fungal agents contain mycoviruses, until recently, their possible direct effects on human health, including carcinogenesis and leukemogenesis, had not been explored. In this regard, most studies of fungal agents have rightly concentrated on their mycotoxin formation and effects. Recently, the direct role of yeasts and fungi in the etiology of cancers, including leukemia, have been investigated. While greater attention has been placed on the carcinogenic effects of Candida , the role of filamentous fungi in carcinogenesis has also been explored. Recent findings from studies using the enzyme-linked immunosorbent assay (ELISA) technique indicate that the plasma of patients with acute lymphoblastic leukemia (ALL) uniformly contains antibodies for a certain mycovirus-containing Aspergillus flavus , while controls are negative. The exposure of mononuclear leukocytes from patients with ALL in full remission, and long-term survivors, to the product of this organism was reported to result in the re-development of typical genetics and cell surface phenotypes characteristic of active ALL. Mycoviruses are known to be able to significantly alter the biological characteristics and functions of their host. The possible carcinogenic and leukemogenic role of mycoviruses, with and without their host, needs to be further investigated. Keywords: cancer, leukemia, etiology, mycoviruses, mycotoxins, aflatoxin, viruses, carcinogenesis, leukemogenesis, fungi, parasites

CITATION EXPORT

Cameron K Tebbi. Mycoviruses in Fungi: Carcinogenesis of Fungal Agents May Not Always Be Mycotoxin Related. Journal of Fungi. (2023). https://doi.org/10.3390/jof9030368

AUTHORS

1 · 1 CENTRES

Cameron K Tebbi

1Children’s Cancer Research Group Laboratory, 13719 North Nebraska Avenue, Suite #108, Tampa, FL 33613-3305, USA; [email protected]