BMJ Case Reports · 4 authors, 2 centres
This summary was generated by AI from a single paper. It has not been reviewed by a clinician and is not clinical advice. Verify against the source before acting on it.
This paper describes two cases of acute colchicine-induced myopathy where myoedema, a mounding phenomenon elicited by muscle percussion, was present. The authors suggest myoedema can be a useful bedside sign for diagnosing this condition, especially where advanced testing is unavailable.
The paper presents two case reports of patients who developed acute colchicine-induced myopathy. Both patients, with pre-existing kidney disease, presented with acute flaccid weakness and were initially suspected of having Guillain-Barré syndrome. Investigations showed elevated serum creatine kinase in one case, myotonic discharges on needle electromyogram in both, and muscle biopsy findings of necrosis and vacuoles in the first case. After discontinuing colchicine, both patients showed gradual recovery of muscle strength and resolution of myoedema at 2-week follow-up.
